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Wertheim, JO, Hostager, R, Ryu, D, Merkel, K, Angedakin, S, Arandjelovic, M, Ayimisin, EA, Babweteera, F, Bessone, M, Brun-Jeffery, KJ, Dieguez, P, Eckardt, W, Fruth, B, Herbinger, I, Jones, S, Kuehl, H, Langergraber, KE, Lee, K, Madinda, NF, Metzger, S et al (2021) Discovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2. Molecular Biology and Evolution, 38 (7). pp. 2818-2830. ISSN 1537-1719
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Abstract
Viruses closely related to human pathogens can reveal the origins of human infectious diseases. Human herpes simplexvirus type 1 (HSV-1) and type 2 (HSV-2) are hypothesized to have arisen via host-virus codivergence and crossspecies transmission. We report the discovery of novel herpes simplexviruses during a large-scale screening of fecal samples from wild gorillas, bonobos, and chimpanzees. Phylogenetic analysis indicates that, contrary to expectation, simplexviruses from these African apes are all more closely related to HSV-2 than to HSV-1. Molecular clock-based hypothesis testing suggests the divergence between HSV-1 and the African great ape simplexviruses likely represents a codivergence event between humans and gorillas. The simplexviruses infecting African great apes subsequently experienced multiple cross-species transmission events over the past 3 My, the most recent of which occurred between humans and bonobos around 1 Ma. These findings revise our understanding of the origins of human herpes simplexviruses and suggest that HSV-2 is one of the earliest zoonotic pathogens.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 0601 Biochemistry and Cell Biology, 0603 Evolutionary Biology, 0604 Genetics |
| Subjects: | G Geography. Anthropology. Recreation > GE Environmental Sciences Q Science > QH Natural history > QH301 Biology Q Science > QL Zoology Q Science > QR Microbiology > QR355 Virology |
| Divisions: | Biological and Environmental Sciences (from Sep 19) |
| Publisher: | Oxford University Press (OUP) |
| Related URLs: | |
| Date of acceptance: | 15 January 2021 |
| Date of first compliant Open Access: | 22 March 2022 |
| Date Deposited: | 22 Mar 2022 16:12 |
| Last Modified: | 17 Oct 2022 12:07 |
| DOI or ID number: | 10.1093/molbev/msab072 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/16533 |
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