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Mazidi, M, Davies, IG, Penson, P, Rikkonen, T and Isanejad, M (2022) Lifetime serum concentration of 25-hydroxyvitamin D 25(OH) is associated with hand grip strengths: insight from a Mendelian randomisation. Age and ageing, 51 (4). ISSN 0002-0729
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Lifetime serum concentration of 25-hydroxyvitamin D 25(OH) is associated with hand grip strengths insight from a Mendelian randomisation.pdf - Published Version Available under License Creative Commons Attribution Non-commercial. Download (417kB) | Preview |
Abstract
Clinical trials have suggested that increased 25-hydroxyvitamin D (25(OH)D) has positive effect on hand grip strength. This Mendelian randomisation (MR) was implemented using summary-level data from the largest genome-wide association studies on vitamin D (n = 73,699) and hand grip strength. Inverse variance weighted method (IVW) was used to estimate the causal estimates. Weighted median (WM)-based method, MR-Egger and leave-one-out were applied as sensitivity analysis. Results showed that genetically higher-serum 25(OH)D levels had a positive effect on both right hand grip (IVW = Beta: 0.038, P = 0.030) and left hand grip (IVW = Beta: 0.034, P = 0.036). There was a low likelihood (statistically insignificant) of heterogeneity and pleiotropy, and the observed associations were not driven by single single-nucleotide polymorphisms. Furthermore, MR pleiotropy residual sum and outlier did not highlight any outliers. In conclusion, our results highlighted the causal and beneficial effect of serum 25(OH) D on right- and left-hand grip strengths.
| Item Type: | Article |
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| Uncontrolled Keywords: | Humans; Vitamin D; Hand Strength; Polymorphism, Single Nucleotide; Genome-Wide Association Study; Mendelian Randomization Analysis; Mendelian randomisation; grip strength; older people; vitamin D; Genome-Wide Association Study; Hand Strength; Humans; Mendelian Randomization Analysis; Polymorphism, Single Nucleotide; Vitamin D; Geriatrics; 1103 Clinical Sciences; 1117 Public Health and Health Services; 1701 Psychology |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Sport & Exercise Sciences Pharmacy & Biomolecular Sciences |
| Publisher: | Oxford University Press (OUP) |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 23 May 2022 10:07 |
| Last Modified: | 23 May 2022 10:15 |
| DOI or ID number: | 10.1093/ageing/afac079 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/16685 |
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