Fawcett, SA, Al Kassas, R, Dykes, IM, Hughes, AT, Ghali, F and Ross, K (2022) A Time to Heal: MicroRNA and Circadian Dynamics in Cutaneous Wound Repair. Clinical Science, 136 (8). pp. 579-597. ISSN 0143-5221

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Abstract

Many biological systems have evolved circadian rhythms based on the daily cycles of daylight and darkness on Earth. Such rhythms are synchronised or entrained to 24-hour cycles, predominantly by light, and disruption of the normal circadian rhythms has been linked to elevation of multiple health risks. The skin serves as a protective barrier to prevent microbial infection and maintain homeostasis of the underlying tissue and the whole organism. However, in chronic non-healing wounds such as diabetic foot ulcers, pressures sores, venous and arterial ulcers, a variety of factors conspire to prevent wound repair. On the other hand, keloids and hypertrophic scars arise from over-active repair mechanisms that fail to cease in a timely fashion, leading to excessive production of extracellular matrix components such as such as collagen. Recent years have seen huge increases in our understanding of the functions of microRNAs (miRNA) in wound repair. Concomitantly, there has been growing recognition of miRNA roles in circadian processes, either as regulators or targets of clock activity or direct responders to external circadian stimuli. In addition, miRNAs are now known to function as intercellular signalling mediators through extracellular vesicles. In this review, we explore the intersection of mechanisms by which circadian and miRNA responses interact with each other in relation to wound repair in the skin, using keratinocytes, macrophages and fibroblasts as exemplars. We highlight areas for further investigation to support the development of translational insights to support circadian medicine in the context of these cells.

Item Type:	Article
Uncontrolled Keywords:	circadian clock,; exosomes; keratinocytes; skin, wound healing; microRNA; Cardiovascular System & Hematology; 11 Medical and Health Sciences
Subjects:	Q Science > QH Natural history > QH301 Biology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RL Dermatology R Medicine > RS Pharmacy and materia medica
Divisions:	Biological & Environmental Sciences (from Sep 19) Computer Science & Mathematics Pharmacy & Biomolecular Sciences
Publisher:	Portland Press
SWORD Depositor:	A Symplectic
Date Deposited:	25 Apr 2022 14:42
Last Modified:	25 Apr 2022 14:45
DOI or ID number:	10.1042/CS20220011
URI:	https://researchonline.ljmu.ac.uk/id/eprint/16708

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