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Mantle, D, Turton, N and Hargreaves, IP (2022) Multiple System Atrophy: Role Of Coenzyme Q10. Journal of Clinical and Medical Research, 4 (2). pp. 1-7.
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New MSA paper 13.05.22.pdf - Published Version Available under License Creative Commons Attribution. Download (304kB) | Preview |
Abstract
Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by a variable combination of autonomic failure, Parkinsonism, and ataxia. There is currently no treatment available to halt or delay progression of this disorder. Biochemically, MSA is characterized by mitochondrial dysfunction, oxidative stress, and inflammation. In the present article we have therefore reviewed the potential role of coenzyme Q10 (CoQ10) in the pathogenesis and treatment of MSA, on the basis of its role in mitochondrial function, and its antioxidant and anti-inflammatory activities, as well as its reported depletion in blood and cerebellar tissue from MSA patients.
| Item Type: | Article |
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| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Mapsci Digital Publisher OPC Pvt. Ltd. |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 13 May 2022 11:38 |
| Last Modified: | 13 May 2022 11:45 |
| DOI or ID number: | 10.37191/mapsci-2582-4333-4(2)-112 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/16846 |
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