Bijak, M, Schmoll, M, Jarvis, JC, Unger, E and Lanmueller, H (2020) MiniVStimA: A miniaturized easy to use implantable electrical stimulator for small laboratory animals. PLoS One, 15 (10). ISSN 1932-6203

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Abstract

According to PubMed, roughly 10% of the annually added publications are describing findings from the small animal model (mice and rats), including investigations in the field of muscle physiology and training. A subset of this research requires neural stimulation with flexible adjustments of stimulation parameters, highlighting the need for reliable implantable electrical stimulators, small enough (~1 cm3), that even mice can tolerate them without impairing their movement. The MiniVStimA is a battery-powered implant for nerve stimulation with an outer diameter of 15 mm and an encapsulated volume of 1.2 cm3 in its smallest variation. It can be pre-programmed according to the experimental protocol and controlled after implantation with a magnet. It delivers constant current charge-balanced monophasic rectangular pulses up to 2 mA and 1 ms phase width (1 kΩ load). The circuitry is optimized for small volume and energy efficiency. Due to the variation of the internal oscillator (31 kHz ± 10%), calibration measures must be implemented during the manufacturing process, which can reduce the deviation of the frequency related parameters down to ± 1%. The expected lifetime of the smaller (larger) version is 100 (480) days for stimulation with 7 Hz all day and 10 (48) days for stimulation with 100 Hz. Devices with complex stimulation patterns for nerve stimulation have been successfully used in two in-vivo studies, lasting up to nine weeks. The implant worked fully self-contained while the animal stayed in its familiar environment. External components are not required during the entire time.

Item Type:	Article
Uncontrolled Keywords:	Science & Technology; Multidisciplinary Sciences; Science & Technology - Other Topics; WEIGHT-LIFTING EXERCISE; DEEP BRAIN-STIMULATION; SKELETAL-MUSCLE; HINDLIMB MUSCLES; DEVICE; TRANSFORMATION; COMMUNICATION; HYPERTROPHY; DESIGN; MODEL; Animals; Animals, Laboratory; Mice; Rats; Rats, Wistar; Equipment Design; Electric Stimulation; Electrodes, Implanted; Female; Animals; Animals, Laboratory; Electric Stimulation; Electrodes, Implanted; Equipment Design; Female; Mice; Rats; Rats, Wistar; General Science & Technology
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport & Exercise Sciences
Publisher:	Public Library of Science
SWORD Depositor:	A Symplectic
Date Deposited:	09 Jun 2022 11:13
Last Modified:	09 Jun 2022 11:15
DOI or ID number:	10.1371/journal.pone.0241638
URI:	https://researchonline.ljmu.ac.uk/id/eprint/17043

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