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Carswell, AlT, Jackson, S, Swinton, P, O'Leary, TJ, Tang, JCY, Oliver, SJ, Sale, C, Izard, RM, Walsh, NP, Fraser, WD and Greeves, JP (2022) Vitamin D Metabolites are Associated with Physical Performance in Young Healthy Adults. Medicine and science in sports and exercise. ISSN 0195-9131
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Abstract
Purpose
To determine vitamin D metabolites and vitamin D receptor (VDR) single-nucleotide polymorphisms (SNPs) relationships with physical performance.
Methods
In 1205 men and 322 women (94.8% white Caucasian, 22.0 ± 2.8 years) commencing military training, we measured: serum vitamin D metabolites (25-hydroxyvitamin D (25(OH)D) and 24,25-dihydroxyvitamin D (24,25(OH)2D) by high-performance liquid chromatography tandem mass spectrophotometry, and 1,25-dihydroxyvitamin D (1,25(OH)2D) by immunoassay); VDR SNPs (rs2228570, rs4516035, and rs7139166 by polymerase chain reaction genotyping); and endurance performance by 2.4 km run, muscle strength by maximal dynamic lift, and muscle power by maximal vertical jump.
Results
Serum 25(OH)D was negatively associated with 2.4 km run time and positively associated with muscle power (β = –12.0 and 90.1), 1,25(OH)2D was positively associated with run time and negatively associated with strength and muscle power (β = 5.6, –1.06, and –38.4), and 24,25(OH)2D was negatively associated with run time (β = –8.9; P < 0.01), after controlling for age, sex, smoking, alcohol, physical activity, time outdoors, season, and BMI. Vitamin D metabolites (25(OH)D, 1,25(OH)2D, and 24,25(OH)2D) together explained variances of 5.0% in run time, 0.7% in strength, and 0.9% in muscle power (ΔF P < 0.001). All performance measures were superior with low 1,25(OH)2D:24,25(OH)2D ratio (P < 0.05). VDR SNPs were not associated with physical performance (ΔF P ≥ 0.306).
Conclusions
Vitamin D metabolites accounted for a small portion of variance in physical performance. Associations between vitamin D metabolites and run time were the most consistent. VDR SNPs explained no variance in performance. Greater conversion of 25(OH)D to 24,25(OH)2D, relative to 1,25(OH)2D (i.e., low 1,25(OH)2D:24,25(OH)2D ratio), was favourable for performance, indicating 24,25(OH)2D may have a role in optimising physical performance.
| Item Type: | Article |
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| Additional Information: | This is a non-final version of an article published in final form in Carswell, Alexander T.1; Jackson, Sarah2; Swinton, Paul3; O’Leary, Thomas J.2,4; Tang, Jonathan C. Y.1; Oliver, Samuel J.5; Sale, Craig6; Izard, Rachel M.7; Walsh, Neil P.8; Fraser, William D.1,9; Greeves, Julie P.1,2,4 Vitamin D Metabolites are Associated with Physical Performance in Young Healthy Adults, Medicine & Science in Sports & Exercise: June 29, 2022 - Volume - Issue - 10.1249/MSS.0000000000002987 doi: 10.1249/MSS.0000000000002987 |
| Uncontrolled Keywords: | 1106 Human Movement and Sports Sciences; 1116 Medical Physiology; 1117 Public Health and Health Services; Sport Sciences |
| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Ovid Technologies (Wolters Kluwer Health) |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 11 Jul 2022 12:33 |
| Last Modified: | 29 Jun 2023 00:50 |
| DOI or ID number: | 10.1249/mss.0000000000002987 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/17204 |
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