Tools
Tools
Prokopidis, K, Kirwan, RP, Giannos, P, Triantafyllidis, KK, Kechagias, KS, Forbes, SC and Candow, DG (2022) The impact of branched-chain amino acid supplementation on measures of glucose homeostasis in individuals with hepatic disorders: A systematic review of clinical studies. Journal of Human Nutrition and Dietetics. ISSN 0952-3871
|
Text
The impact of branched-chain amino acid supplementation on measures of glucose homeostasis in individuals with hepatic disorders.pdf - Published Version Available under License Creative Commons Attribution. Download (869kB) | Preview |
Abstract
BACKGROUND: Branched chain amino acid (BCAA) supplementation may influence glucose metabolism in individuals with impaired glycemic profile. This systematic review investigated the effects of isolated BCAA supplementation on measures of glucose homeostasis in individuals with hepatic disorders. METHODS: We searched PubMed, Web of Science, Cochrane Library, and Scopus for published clinical trials that investigated the effects of isolated BCAA supplementation on measures of glucose homeostasis, including serum glucose and insulin, glycated hemoglobin (HbA1c) levels, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) scores. RESULTS: Eleven trials met the inclusion criteria. Only one study revealed a decrease in serum glucose from BCAA supplementation compared to three studies that showed increases. Five studies demonstrated no significant changes in serum glucose, and two studies displayed no changes in HbA1c following BCAA supplementation. Serum levels of insulin were decreased in three studies, remained unchanged in one, whilst increased in the remaining three studies. BCAA supplementation reduced HOMA-IR scores in two studies, increased HOMA-IR scores in another two or resulted in no changes in two other studies. CONCLUSIONS: BCAA supplementation in isolation had no effect on overall glucose homeostasis in individuals with hepatic disorders, although some improvements on serum insulin levels and HOMA-IR scores were observed. Overall, there is little evidence to support the utilization of BCAA supplementation as a potential nutritional strategy for improving measures of glucose homeostasis in individuals with hepatic disorders. This article is protected by copyright. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BCAA; branched chain amino acids; hepatic disorders; liver disease; nutritional supplementation; 0601 Biochemistry and Cell Biology; 1111 Nutrition and Dietetics; Nutrition & Dietetics |
| Subjects: | Q Science > QP Physiology |
| Divisions: | Biological & Environmental Sciences (from Sep 19) |
| Publisher: | Wiley |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 01 Sep 2022 14:02 |
| Last Modified: | 17 Oct 2022 10:45 |
| DOI or ID number: | 10.1111/jhn.13076 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/17477 |
 |
View Item |