Anwer, H, O'Dea, RE, Mason, D, Zajitschek, S, Klinke, A, Reid, M, Hesselson, D, Noble, DWA, Morris, MJ, Lagisz, M and Nakagawa, S (2022) The effects of an obesogenic diet on behavior and cognition in zebrafish (Danio rerio): Trait average, variability, repeatability, and behavioral syndromes. Ecology and evolution, 12 (11). ISSN 2045-7758

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Abstract

The obesity epidemic, largely driven by the accessibility of ultra-processed high-energy foods, is one of the most pressing public health challenges of the 21st century. Consequently, there is increasing concern about the impacts of diet-induced obesity on behavior and cognition. While research on this matter continues, to date, no study has explicitly investigated the effect of obesogenic diet on variance and covariance (correlation) in behavioral traits. Here, we examined how an obesogenic versus control diet impacts means and (co-)variances of traits associated with body condition, behavior, and cognition in a laboratory population of ~160 adult zebrafish (<i>Danio rerio</i>). Overall, an obesogenic diet increased variation in several zebrafish traits. Zebrafish on an obesogenic diet were significantly heavier and displayed higher body weight variability; fasting blood glucose levels were similar between control and treatment zebrafish. During behavioral assays, zebrafish on the obesogenic diet displayed more exploratory behavior and were less reactive to video stimuli with conspecifics during a personality test, but these significant differences were sex-specific. Zebrafish on an obesogenic diet also displayed repeatable responses in aversive learning tests whereas control zebrafish did not, suggesting an obesogenic diet resulted in more consistent, yet impaired, behavioral responses. Where behavioral syndromes existed (inter-class correlations between personality traits), they did not differ between obesogenic and control zebrafish groups. By integrating a multifaceted, holistic approach that incorporates components of (co-)variances, future studies will greatly benefit by quantifying neglected dimensions of obesogenic diets on behavioral changes.

Item Type:	Article
Uncontrolled Keywords:	anxiety; cognition; high fat diet; obesogenic diet; personality; variance; zebrafish; 0602 Ecology; 0603 Evolutionary Biology
Subjects:	G Geography. Anthropology. Recreation > GE Environmental Sciences Q Science > QH Natural history > QH301 Biology Q Science > QL Zoology
Divisions:	Biological & Environmental Sciences (from Sep 19)
Publisher:	Wiley
SWORD Depositor:	A Symplectic
Date Deposited:	08 Dec 2022 12:43
Last Modified:	08 Dec 2022 12:43
DOI or ID number:	10.1002/ece3.9511
URI:	https://researchonline.ljmu.ac.uk/id/eprint/18343

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