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Olax Subscorpioidea Oliv. (Olacaceae): An Ethnomedicinal and Pharmacological Review

Adekunle, Y, Samuel, BB, Fatokun, AA, Nahar, L and Sarker, SD (2022) Olax Subscorpioidea Oliv. (Olacaceae): An Ethnomedicinal and Pharmacological Review. Journal of Natural Products Discovery, 1 (2). ISSN 2755-1997

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Open Access URL: https://doi.org/10.24377/jnpd.article673 (Published)


Background: Olax subscorpioideaOliv. (Olacaceae) is a woody shrub that is widely distributed in Africa. It hastrado-medicinal importance and is used in the treatment of asthma, cancer, convulsion, diabetes, intestinal worm infections, jaundice, mental illnesses, neurodegenerative disorders, sexually transmitted infections, swellings and rheumatism, and yellow fever. Aims: To review available literature on the phytochemistry, ethnobotany, pharmacology and toxicity of Olax subscorpioideaOliv.
Method:Published findings were searched in online databases such as Web of Science, Scopus, Pubmed, Google Scholar and other relevant sources, and the data were sorted by relevance. Combinations of keywords used in the search include Olax subscorpioidea, Olacaceae, Olax, Ewe Ifon, and African medicinal plants.
Results: The presence ofalkaloids, anthraquinones, cardiac glycosides, flavonoids, phenoliccompounds, proanthocyanidins, saponins, tannins and triterpeneshasbeen reported from O. subscorpioidea. Several secondary metabolites have been identified, importantly the cytotoxic santalbic acid from the seeds. Bioactivity studies on this plant demonstrated its medicinal potential mainly asan analgesic, anthelmintic, anti-arthritic, antidepressant, antihyperglycaemic, anti-inflammatory, antioxidant, antimalarial and antimicrobial agent. Oral acute toxicity of the leaf extracts in rats appears to be negligible.
Conclusion: Published literature available to date onO. subscorpioideaOliv. provides some preliminary scientific basis for the ethnomedicinal uses of this plant. However, some ethnomedicinal uses have not been scientifically, only a limited amount of information is available on properly isolated and identified phytochemicals from this plant that link to its bioactivities.

Item Type: Article
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: LJMU
SWORD Depositor: A Symplectic
Date Deposited: 13 Dec 2022 12:28
Last Modified: 13 Dec 2022 12:30
DOI or ID number: doi.org/10.24377/jnpd.article673
URI: https://researchonline.ljmu.ac.uk/id/eprint/18385
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