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Viggars, MR, Sutherland, H, Lanmüller, H, Schmoll, M, Bijak, M and Jarvis, JC (2022) Adaptation of the transcriptional response to resistance exercise over 4 weeks of daily training. FASEB Journal, 37 (1). ISSN 0892-6638
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Abstract
We present the time course of change in the muscle transcriptome 1 h after the last exercise bout of a daily resistance training program lasting 2, 10, 20, or 30 days. Daily exercise in rat tibialis anterior muscles (5 sets of 10 repetitions over 20 min) induced progressive muscle growth that approached a new stable state after 30 days. The acute transcriptional response changed along with progressive adaptation of the muscle phenotype. For example, expression of type 2B myosin was silenced. Time courses recently synthesized from human exercise studies do not demonstrate so clearly the interplay between the acute exercise response and the longer-term consequences of repeated exercise. We highlight classes of transcripts and transcription factors whose expression increases during the growth phase and declines again as the muscle adapts to a new daily pattern of activity and reduces its rate of growth. Myc appears to play a central role.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Muscles; Animals; Humans; Rats; Acclimatization; Phenotype; Resistance Training; Physical Conditioning, Human; Humans; Animals; Rats; Resistance Training; Acclimatization; Physical Conditioning, Human; Muscles; Phenotype; 0601 Biochemistry and Cell Biology; 0606 Physiology; 1116 Medical Physiology; Biochemistry & Molecular Biology |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology R Medicine > RC Internal medicine > RC1200 Sports Medicine G Geography. Anthropology. Recreation > GV Recreation Leisure > GV561 Sports > GV711 Coaching G Geography. Anthropology. Recreation > GV Recreation Leisure > GV561 Sports |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Wiley |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 18 Jan 2023 12:11 |
| Last Modified: | 18 Jan 2023 12:11 |
| DOI or ID number: | 10.1096/fj.202201418R |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/18672 |
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