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Uban, KA, Jonker, D, Donald, KA, Bodison, SC, Brooks, SJ, Kan, E, Steigelmann, B, Roos, A, Marshall, A, Adise, S, Butler-Kruger, L, Melly, B, Narr, KL, Joshi, SH, Odendaal, HJ, Sowell, ER and Stein, DJ (2023) Associations between community-level patterns of prenatal alcohol and tobacco exposure on brain structure in a non-clinical sample of 6-year-old children: a South African pilot study. Acta Neuropsychiatrica. ISSN 0924-2708
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Associations between community-level patterns of prenatal alcohol and tobacco exposure.pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (1MB) | Preview |
Abstract
The current small study utilized prospective data collection of patterns of prenatal alcohol and tobacco exposure (PAE and PTE) to examine associations with structural brain outcomes in 6-year-olds, and served as a pilot to determine the value of prospective data describing community-level patterns of PAE and PTE in a non-clinical sample of children. Participants from the Safe Passage Study in pregnancy were approached when their child was ∼6 years old and completed structural brain magnetic resonance imaging (MRI) to examine with archived PAE and PTE data (n=51 children-mother dyads). Linear regression was used to conduct whole brain structural analyses, with FDR correction, to examine: a) main effects of PAE, PTE and their interaction; and b) predictive potential of data that reflects <i>patterns</i> of PAE and PTE (e.g., quantity, frequency, and timing (QFT)). Associations between PAE, PTE and their interaction with brain structural measures demonstrated unique profiles of cortical and subcortical alterations that were distinct between PAE only, PTE only and their interactive effects. Analyses examining associations between patterns of PAE and PTE (e.g., QFT) were able to significantly detect brain alterations (that survived FDR correction) in this small non-clinical sample of children. These findings support the hypothesis that considering QFT and co-exposures is important for identifying brain alterations following PAE and/or PTE in a small group of young children. Current results demonstrate that teratogenic outcomes on brain structure differ as a function PAE, PTE or their co-exposures, as well as the pattern (QFT) or exposure.
| Item Type: | Article |
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| Uncontrolled Keywords: | Teratogen; brain structure; children; low-middle income country (LMIC); prenatal alcohol exposure (PAE); prenatal tobacco exposure (PTE); 11 Medical and Health Sciences; 17 Psychology and Cognitive Sciences; Psychiatry |
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RG Gynecology and obstetrics |
| Divisions: | Psychology (from Sep 2019) |
| Publisher: | Cambridge University Press (CUP) |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 31 Jan 2023 10:35 |
| Last Modified: | 26 Jul 2023 00:50 |
| DOI or ID number: | 10.1017/neu.2022.34 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/18764 |
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