Proksch, J, Vargas Luna, JL, Eickhoff, S, Mayr, W and Jarvis, JC (2022) The evoked compound nerve action potential is shaped by the electrical pulse-width. Current Directions in Biomedical Engineering, 8 (3). pp. 37-40. ISSN 2364-5504

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Abstract

Introduction: Despite its central role in medicine electrical stimulation (ES) is still limited by its selectivity. Different reports did assess effects of different waveforms, intensities, and frequency on the activation threshold of nerve fibres with different diameters. We aimed to extend this knowledge by investigating the effect of short monophasic rectangular pulses (1, 2, 5, 10, 50, 100 and 200 μs) on the recruitment order. Methods:The sciatic nerve of rats was stimulated, and the evoked compound nerve action potential (CNAP) measured at two sites on the tibialis nerve, using epineural electrodes. Changes in delay, amplitude, and the shape of the CNAP were analyzed. Results:The amplitude and delay of the CNAP were significantly affected by the pulse-width (PW). The delay and duration of the compound nerve action potential increased with longer PW, while the amplitude decreased. Discussion:Found changes are likely caused by changes in the time point of excitation of individual neuron fibres, depending on electrical field strength and exposure time. This might be of particular interest when selecting PWs for design and validation of stimulation patterns and analysis of experimental and clinical observations.

Item Type:	Article
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport & Exercise Sciences
Publisher:	De Gruyter
SWORD Depositor:	A Symplectic
Date Deposited:	14 Feb 2023 13:23
Last Modified:	14 Feb 2023 13:30
DOI or ID number:	10.1515/cdbme-2022-2010
URI:	https://researchonline.ljmu.ac.uk/id/eprint/18898

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