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Heseltine, T, Hughes, E, Mattew, J, Murray, S, Ortega-Martorell, S, Olier, I, Dey, D, Lip, GYH and Khoo, S (2023) The association of epicardial adipose tissue volume and density with coronary calcium in HIV-positive and HIV-negative patients. Journal of Infection. ISSN 0163-4453
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The association of epicardial adipose tissue and CVD in HIV.pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (504kB) | Preview |
Abstract
Aims: We sought to assess and compare the association of epicardial adipose tissue (EAT) with cardiovascular disease (CVD) in HIV-positive and HIV-negative groups
Methods and Results: Using existing clinical databases we analysed 700 patients (195 HIV-positive, 505 HIV-negative). CVD was quantified by the presence of coronary calcification from both dedicated cardiac computed tomography (CT) and non-dedicated CT of the thorax. Epicardial adipose tissue (EAT) was quantified using dedicated software. The HIV-positive group had lower mean age (49.2 versus 57.8, p<0.005), higher proportion of male sex (75.9% versus 48.1%, p<0.005) and lower rates of coronary calcification (29.2% versus 58.2%, p<0.005). Mean EAT volume was also lower in the HIV-positive group (68mm3 versus 118.3mm3, p<0.005). Multiple linear regression demonstrated EAT volume was associated hepatosteatosis (HS) in the HIV-positive group but no the HIV-negative group after adjustment for BMI (p<0.005 versus p=0.066). In the multivariate analysis, after adjustment for CVD risk factors, age, sex, statin use and body mass index (BMI), EAT volume and hepatosteatosis were significantly associated with coronary calcification (odds ratio [OR] 1.14, p<0.005 and OR 3.17, p<0.005 respectively). In the HIV-negative group the only significant association with EAT volume after adjustment was total cholesterol (OR 0.75, p=0.012).
Conclusions: We demonstrated a strong and significant independent association of EAT volume and coronary calcium, after adjustment, in HIV-positive group but not in the HIV-negative group. This result hints at differences in the mechanistic drivers of atherosclerosis between HIV-positive and HIV-negative groups.
| Item Type: | Article |
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| Uncontrolled Keywords: | 1103 Clinical Sciences; Microbiology |
| Subjects: | Q Science > QP Physiology Q Science > QR Microbiology |
| Divisions: | Computer Science & Mathematics |
| Publisher: | Elsevier BV |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 29 Mar 2023 11:02 |
| Last Modified: | 16 Feb 2024 00:50 |
| DOI or ID number: | 10.1016/j.jinf.2023.02.020 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/18936 |
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