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Mantle, D, Lopez-Lluch, G and Hargreaves, IP (2023) Coenzyme Q10 Metabolism: A Review of Unresolved Issues. International Journal of Molecular Sciences, 24 (3). ISSN 1661-6596
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Abstract
The variable success in the outcome of randomised controlled trials supplementing coenzyme Q10 (CoQ10) may in turn be associated with a number of currently unresolved issues relating to CoQ10 metabolism. In this article, we have reviewed what is currently known about these factors and where gaps in knowledge exist that need to be further elucidated. Issues addressed include (i) whether the bioavailability of CoQ10 could be improved; (ii) whether CoQ10 could be administered intravenously; (iii) whether CoQ10 could be administered via alternative routes; (iv) whether CoQ10 can cross the blood-brain barrier; (v) how CoQ10 is transported into and within target cells; (vi) why some clinical trials supplementing CoQ10 may have been unsuccessful; and (vii) which is the most appropriate tissue for the clinical assessment of CoQ10 status.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | bioavailability; blood-brain barrier; coenzyme Q10; intracellular transporters; intravenous delivery; Ubiquinone; Antioxidants; Biological Availability; Biological Transport; 0399 Other Chemical Sciences; 0604 Genetics; 0699 Other Biological Sciences; Chemical Physics |
| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | MDPI |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 20 Feb 2023 14:29 |
| Last Modified: | 20 Feb 2023 14:29 |
| DOI or ID number: | 10.3390/ijms24032585 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/18937 |
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