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Harvie, M, French, DP, Pegington, M, Lombardelli, C, Krizak, S, Sellers, K, Barrett, E, Gareth Evans, D, Cutress, R, Wilding Rgn, A, Graves, L and Howell, A (2023) Randomised controlled trial of breast cancer and multiple disease prevention weight loss programmes vs written advice amongst women attending a breast cancer family history clinic. British Journal of Cancer. ISSN 0007-0920
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Abstract
Overweight and obesity are common amongst women attending breast cancer Family History, Risk and Prevention Clinics (FHRPCs). Overweight increases risk of breast cancer (BC) and conditions including1 cardiovascular disease (CVD) and type-2 diabetes (T2D). Clinics provide written health behaviour advice with is likely to have minimal effects. We assessed efficacy of two remotely delivered weight loss programmes vs. written advice. 210 women with overweight or obesity attending three UK FHRPCs were randomised to either a BC prevention programme (BCPP) framed to reduce risk of BC (n = 86), a multiple disease prevention programme (MDPP) framed to reduce risk of BC, CVD and T2D (n = 87), or written advice (n = 37). Change in weight and health behaviours were assessed at 12-months. Weight loss at 12 months was -6.3% (-8.2, -4.5) in BCPP, -6.0% (-7.9, -4.2) in MDPP and -3.3% (-6.2, -0.5) in the written group (p = 0.451 across groups). The percentage losing ≥10% weight in these groups were respectively 34%, 23% and 14% (p = 0.038 across groups). BCPP and MDPP programmes resulted in more women achieving ≥10% weight loss, but no evidence of additional benefits of MDPP. A multicentre RCT to test the BCPP across UK FHRPCs is warranted.
Clinical Trial Registration ISRCTN16431108.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1112 Oncology and Carcinogenesis; 1117 Public Health and Health Services; Oncology & Carcinogenesis |
| Subjects: | T Technology > TX Home economics > TX341 Nutrition. Foods and food supply R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Springer Nature |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 28 Feb 2023 10:33 |
| Last Modified: | 28 Feb 2023 10:45 |
| DOI or ID number: | 10.1038/s41416-023-02207-z |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/18966 |
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