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Tsoneva, DK, Ivanov, MN, Conev, NV, Manev, R, Stoyanov, DS and Vinciguerra, M (2023) Circulating Histones to Detect and Monitor the Progression of Cancer. International Journal of Molecular Sciences, 24 (2). ISSN 1661-6596
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Circulating Histones to Detect and Monitor the Progression of Cancer.pdf - Published Version Available under License Creative Commons Attribution. Download (881kB) | Preview |
Abstract
Liquid biopsies have emerged as a minimally invasive cancer detection and monitoring method, which could identify cancer-related alterations in nucleosome or histone levels and modifications in blood, saliva, and urine. Histones, the core component of the nucleosome, are essential for chromatin compaction and gene expression modulation. Increasing evidence suggests that circulating histones and histone complexes, originating from cell death or immune cell activation, could act as promising biomarkers for cancer detection and management. In this review, we provide an overview of circulating histones as a powerful liquid biopsy approach and methods for their detection. We highlight current knowledge on circulating histones in hematologic malignancies and solid cancer, with a focus on their role in cancer dissemination, monitoring, and tumorigenesis. Last, we describe recently developed strategies to identify cancer tissue-of-origin in blood plasma based on nucleosome positioning, inferred from nucleosomal DNA fragmentation footprint, which is independent of the genetic landscape.
| Item Type: | Article |
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| Uncontrolled Keywords: | Chromatin; Nucleosomes; Humans; Neoplasms; Histones; cancer; cell-free DNA; histones; liquid biopsy; Humans; Histones; Nucleosomes; Chromatin; Neoplasms; 0399 Other Chemical Sciences; 0604 Genetics; 0699 Other Biological Sciences; Chemical Physics |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Nursing & Allied Health |
| Publisher: | MDPI AG |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 02 Mar 2023 10:26 |
| Last Modified: | 02 Mar 2023 10:26 |
| DOI or ID number: | 10.3390/ijms24020942 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/18985 |
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