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Cherian, T, Ragavendran, C, Remesh, RKV, Jacob, J, Jamal, W, Kamaraj, C and Nakouti, I (2023) Bio-functionalization, stabilization and potential functionalities of hyaluronate macromolecules capped copper oxide nanoparticles. Journal of Environmental Chemical Engineering, 11 (6). ISSN 2213-3437
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Bio-functionalization, stabilization and potential functionalities of hyaluronate macromolecules capped copper oxide nanoparticles.pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (2MB) | Preview |
Abstract
The optical-electrical properties of CuO-NPs (copper oxide nanoparticles) are being expanded widely for high-technological uses. In accordance with the idea of an eco-friendly synthesis process, CuO-NPs were synthesized utilizing a safer method; stabilized by biopolymer sodium hyaluronate (SH) rather than a hazardous substance. Using one variable at one time method with constant reaction variables, the synthesis parameters were optimized and the characteristics of CuO-NPs were controlled. The resulting particles exhibited restricted distribution, were typically round or oval in form and particle size of 17 ± 1.3 nm (by TEM and SEM), strongly crystalline (by XRD) and were noticeably stable. The experimental analysis of FT-IR documented that the redox reaction between biopolymers and metal cations; coupled by capping effect of thin layer of SH-macromolecules, are primarily responsible for the formation and stabilization of CuO-NPs. Also, CuO-NPs exhibited strong bactericidal (ZOI 22–27 nm; antibiofilm potential 71–85%), anti-diabetic (70–72%), DNA cleavage and antioxidant activity (70–85%). Additionally, SH-stabilized CuO-NPs demonstrated catalytic activity for the reduction of catalytic dyes, degrading at a rate of over 91–93% in about 10–20 min. The current synthetic technique may be applied consecutively to synthesize catalytically active CuO-NPs which exhibited remarkable in-vitro biological and biomedical capabilities, possessing the potential to be exploited as a broad-based agent in a variety of biomedical and industrial processes, including the treatment of wastewater.
| Item Type: | Article |
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| Uncontrolled Keywords: | 0306 Physical Chemistry (incl. Structural); 0904 Chemical Engineering; 0907 Environmental Engineering |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Elsevier BV |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 06 Oct 2023 07:36 |
| Last Modified: | 20 Sep 2024 00:50 |
| DOI or ID number: | 10.1016/j.jece.2023.111051 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/21683 |
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