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Non-pharmacological interventions for depression/anxiety in older adults with physical comorbidities affecting functioning: Systematic review and meta-analysis

Frost, R, Bauernfreund, Y and Walters, K (2018) Non-pharmacological interventions for depression/anxiety in older adults with physical comorbidities affecting functioning: Systematic review and meta-analysis. International Psychogeriatrics, 31 (8). pp. 1121-1136. ISSN 1041-6102

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Abstract

To review the effectiveness of non-pharmacological interventions in older adults with depression or anxiety and comorbidities affecting functioning.Design: Systematic review and meta-analysis of randomized controlled trials, including searches of 10 databases (inception-Jul 2017).Setting: Home/community.Participants: People aged 60 and over experiencing functional difficulties from physical or cognitive comorbidities and have symptoms or a diagnosis of depression and/or anxiety.Interventions: Non-pharmacological interventions targeted at depression/anxiety.Measurements: We extracted outcome data on depressive symptoms, quality of life, functioning, and service use. We used random effects meta-analysis to pool study data where possible. Two authors assessed the risk of bias using the Cochrane Risk of Bias tool.Results: We identified 14 eligible trials including 2099 randomized participants and two subgroup analyses. Problem-solving therapy (PST) reduced short-term clinician-rated depressive symptoms (n = 5 trials, mean difference in Hamilton Depression Rating Scale score -4.94 [95% CI -7.90 to -1.98]) but not remission, with limited evidence for effects on functioning and quality of life. There was limited high-quality evidence for other intervention types. Collaborative care did not appear to affect depressive symptoms, functioning, or quality of life; and had mixed evidence for effects upon remission. No intervention consistently affected service use, but trials were limited by small sample sizes and short follow-up periods. No anxiety interventions were identified.Conclusion: PST may reduce depressive symptoms post-intervention in older people with depression and functional impairments. Collaborative care appears to have few effects in this population. Future research needs to assess cost-effectiveness, long-term outcomes, and anxiety interventions for this population.

Item Type: Article
Uncontrolled Keywords: Humans; Depression; Anxiety; Problem Solving; Psychiatric Status Rating Scales; Psychotherapy; Comorbidity; Quality of Life; Aged; Randomized Controlled Trials as Topic; Physical Conditioning, Human; anxiety; depression; disability; medical comorbidity; meta-analysis; Aged; Anxiety; Comorbidity; Depression; Humans; Physical Conditioning, Human; Problem Solving; Psychiatric Status Rating Scales; Psychotherapy; Quality of Life; Randomized Controlled Trials as Topic; 11 Medical and Health Sciences; 17 Psychology and Cognitive Sciences; Geriatrics
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RA Public aspects of medicine
Divisions: Nursing & Allied Health
Publisher: Cambridge University Press (CUP)
SWORD Depositor: A Symplectic
Date Deposited: 08 Dec 2023 16:56
Last Modified: 08 Dec 2023 16:56
DOI or ID number: 10.1017/S1041610218001564
URI: https://researchonline.ljmu.ac.uk/id/eprint/22037
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