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Bruno, D, Gicas, KM, Jauregi-Zinkunegi, A, Mueller, KD and Lamar, M (2024) Delayed primacy recall performance predicts post mortem Alzheimer's disease pathology from unimpaired ante mortem cognitive baseline. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 16 (1). ISSN 2352-8729
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Delayed primacy recall performance predicts ipost mortemi Alzheimers disease pathology from unimpaired iante mortemi cogniti.pdf - Published Version Available under License Creative Commons Attribution Non-commercial. Download (390kB) | Preview |
Abstract
We propose a novel method to assess delayed primacy in the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) memory test. We then examine whether this measure predicts post mortem Alzheimer's disease (AD) neuropathology in individuals who were clinically unimpaired at baseline. A total of 1096 individuals were selected from the Rush Alzheimer's Disease Center database registry. All participants were clinically unimpaired at baseline, and had subsequently undergone brain autopsy. Average age at baseline was 78.8 (6.92). A Bayesian regression analysis was carried out with global pathology as an outcome; demographic, clinical, and apolipoprotein E (APOE) data as covariates; and cognitive predictors, including delayed primacy. Global AD pathology was best predicted by delayed primacy. Secondary analyses showed that delayed primacy was mostly associated with neuritic plaques, whereas total delayed recall was associated with neurofibrillary tangles. Sex differential associations were observed. We conclude that CERAD-derived delayed primacy is a useful metric for early detection and diagnosis of AD in unimpaired individuals.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Alzheimer's disease; CERAD; memory; neuropathology; serial position; 0604 Genetics; 1109 Neurosciences |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Psychology (from Sep 2019) |
| Publisher: | Wiley |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 09 Feb 2024 14:27 |
| Last Modified: | 09 Feb 2024 14:30 |
| DOI or ID number: | 10.1002/dad2.12524 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/22579 |
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