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Clarkson, GJ and Roesner, S (2022) Synthesis of Benzofuropyridines and Dibenzofurans by a Metalation/Negishi Cross-Coupling/SNAr Reaction Sequence. The Journal of Organic Chemistry, 88 (1). pp. 684-689. ISSN 0022-3263
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Synthesis of Benzofuropyridines and Dibenzofurans by a MetalationNegishi Cross-CouplingSsubNsubAr Reaction Sequence.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Publisher URL: http://doi.org/10.1021/acs.joc.2c02111
Abstract
An efficient methodology for the synthesis of benzofuropyridines and dibenzofurans from fluoropyridines or fluoroarenes and 2-bromophenyl acetates is reported. This streamlined one-pot procedure consists of a four-step directed ortho-lithiation, zincation, Negishi cross-coupling, and intramolecular nucleophilic aromatic substitution, allowing for the facile assembly of a diverse set of fused benzofuro heterocycles.
| Item Type: | Article |
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| Uncontrolled Keywords: | Dibenzofurans; Dibenzofurans; 0304 Medicinal and Biomolecular Chemistry; 0305 Organic Chemistry; Organic Chemistry |
| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | American Chemical Society |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 23 Apr 2024 12:29 |
| Last Modified: | 24 Apr 2024 12:59 |
| DOI or ID number: | 10.1021/acs.joc.2c02111 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/23110 |
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