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Prokopidis, K, Morwani-Mangnani, J, McDowell, G, Lip, GYH, Venturelli, M, Sankaranarayanan, R and Isanejad, M (2024) Sarcopenia is linked to higher levels of B-type natriuretic peptide and its N-terminal fragment in heart failure: a systematic review and meta-analysis. European Geriatric Medicine. ISSN 1878-7649
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Sarcopenia is linked to higher levels of B‑type natriuretic peptide.pdf - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
Aims: Sarcopenia is linked to impaired physical function and exercise tolerance. The aim of this systematic review and meta-analysis was to examine the association of sarcopenia and low appendicular skeletal muscle (ASM) with biomarkers of cardiac function, B-type natriuretic peptide (BNP) and its N-terminal fragment (NT-proBNP), in patients with heart failure (HF). Methods and results: From inception until May 2023, a systematic literature search of observational studies was undertaken utilizing the PubMed, Web of Science, Scopus, and Cochrane Library databases. A meta-analysis employing a random-effects model was used to compute the pooled effects (CRD42023418465). Overall, 16 studies were included in this systematic review and meta-analysis. Our main analysis showed that sarcopenia in HF was linked to significantly higher levels of BNP (MD: 87.76, 95% CI 20.74–154.78, I2 = 61%, P = 0.01) and NT-proBNP (MD: 947.45, 95% CI 98.97–1795.93, I2 = 35%, P = 0.03). Similarly, low ASM was associated with significantly higher levels of BNP (MD: 118.95, 95% CI 46.91–191.00, I2 = 93%, P < 0.01) and NT-proBNP (MD: 672.01, 95% CI 383.72–960.30, I2 = 2%, P < 0.01). The quality of the included cohort studies was considered moderate, using the binary AXIS checklist and the Cochrane Tool to Assess the Risk of Bias in Cohort Studies. Conclusions: In patients with HF, sarcopenia and reduced ASM are associated with considerably higher plasma levels of BNP and NT-proBNP. Future research is required to investigate whether sarcopenia may express dysregulated biomarkers of cardiac function.
| Item Type: | Article |
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| Uncontrolled Keywords: | BNP; Biomarkers; Cardiac function; Heart failure; NT-proBNP; Sarcopenia |
| Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Springer |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 03 May 2024 12:37 |
| Last Modified: | 03 May 2024 12:37 |
| DOI or ID number: | 10.1007/s41999-024-00950-x |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/23173 |
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