Oldfield, L, Stott, M, Hanson, R, Jackson, RJ, Reynolds, W, Chandran-Gorner, V, Van Der Meer, R, Alison, L, Tejeiro, RA, Purewal, T, Ghaneh, P, Palmer, D, Greenhalf, W, Halloran, C and Costello, E (2022) United Kingdom Early Detection Initiative (UK-EDI): protocol for establishing a national multicentre cohort of individuals with new-onset diabetes for early detection of pancreatic cancer. BMJ Open, 12 (10).

Preview

Text Oldfield_etal_BMJO_2022_United_Kingdom_Early_Detection_Initiative_UK_EDI_protocol_for_establishing_a_national_multicentre_cohort.pdf - Published Version Available under License Creative Commons Attribution. Download (540kB) | Preview

Abstract

Introduction Pancreatic cancer is a leading cause of cancer deaths worldwide. Screening for this disease has potential to improve survival. It is not feasible, with current screening modalities, to screen the asymptomatic adult population. However, screening of individuals in high-risk groups is recommended. Our study aims to provide resources and data that will inform strategies to screen individuals with new-onset diabetes (NOD) for pancreatic cancer. Methods and analysis The United Kingdom Early Detection Initiative (UK-EDI) for pancreatic cancer is a national, prospective, observational cohort study that aims to recruit 2500 individuals with NOD (<6 months postdiagnosis) aged 50 years and over, with follow-up every 6 months, over a 3-year period. For study eligibility, diagnosis of diabetes is considered to be clinical measurement of haemoglobin A1c ≥48 mmol/mol. Detailed clinical information and biospecimens will be collected at baseline and follow-up to support the development of molecular, epidemiological and demographic biomarkers for earlier detection of pancreatic cancer in the high-risk NOD group. Socioeconomic impacts and cost-effectiveness of earlier detection of pancreatic cancer in individuals with NOD will be evaluated. The UK-EDI NOD cohort will provide a bioresource for future early detection research to be conducted. Ethics and dissemination The UK-EDI study has been reviewed and approved by the London-West London and GTAC Research Ethics Committee (Ref 20/LO/0058). Study results will be disseminated through presentations at national and international symposia and publication in peer-reviewed, Open Access journals.

Item Type:	Article
Uncontrolled Keywords:	Humans; Pancreatic Neoplasms; Diabetes Mellitus; Cohort Studies; Prospective Studies; Aged; Middle Aged; Multicenter Studies as Topic; Early Detection of Cancer; Observational Studies as Topic; United Kingdom; Glycated Hemoglobin; diabetes & endocrinology; hepatobiliary tumours; pancreatic disease; Aged; Cohort Studies; Diabetes Mellitus; Early Detection of Cancer; Glycated Hemoglobin; Humans; Middle Aged; Multicenter Studies as Topic; Observational Studies as Topic; Pancreatic Neoplasms; Prospective Studies; United Kingdom; 1103 Clinical Sciences; 1117 Public Health and Health Services; 1199 Other Medical and Health Sciences
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions:	Psychology (from Sep 2019)
Publisher:	BMJ Publishing Group
SWORD Depositor:	A Symplectic
Date Deposited:	21 May 2024 13:03
Last Modified:	21 May 2024 13:03
DOI or ID number:	10.1136/bmjopen-2022-068010
URI:	https://researchonline.ljmu.ac.uk/id/eprint/23325

View Item