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Reichert Plaska, C, Heslegrave, A, Bruno, D, Ramos-Cejudo, J, Han Lee, S, Osorio, R, Imbimbo, BP, Zetterberg, H, Blennow, K and Pomara, N (2024) Evidence for reduced anti-inflammatory microglial phagocytic response in late-life major depression. Brain, Behavior, and Immunity, 120. pp. 248-255. ISSN 0889-1591
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Evidence for Reduced Anti-Inflammatory Microglial Phagocytic Response in Late-Life Major Depression.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (2MB) | Preview |
Abstract
Major depressive disorder (MDD) is associated with Alzheimer’s disease (AD) but the precise mechanisms underlying this relationship are not understood. While it is well established that cerebrospinal fluid (CSF) soluble levels of triggering receptor expressed on myeloid cells 2 (sTREM2) increase during early stages of AD, how sTREM2 levels behave in subjects with MDD is not known. In a longitudinal study, we measured CSF sTREM2 levels in 27 elderly cognitively intact individuals with late-life major depression (LLMD) and in 19 healthy controls. We tested the hypothesis that, similarly to what happens in early stages of AD, CSF sTREM2 would be elevated in MDD. In addition, we compared the associations of CSF sTREM2, pro- and anti- inflammatory, and AD biomarkers in LLMD and control subjects. Surprisingly, we found that mean CSF sTREM2 levels were significantly reduced in LLMD compared to controls. This reduction was no longer significant at the 3-year follow-up visit when depression severity improved. In addition, we found that CSF sTREM2 was associated with AD biomarkers and proinflammatory cytokines in controls but not in LLMD. These findings suggest that impaired microglia phagocytic response to AD pathology may be a novel link between MDD and AD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1107 Immunology; 1109 Neurosciences; 1701 Psychology; Neurology & Neurosurgery |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology |
| Divisions: | Psychology (from Sep 2019) |
| Publisher: | Elsevier |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 22 May 2024 10:37 |
| Last Modified: | 20 Jun 2024 09:45 |
| DOI or ID number: | 10.1016/j.bbi.2024.05.030 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/23331 |
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