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Marshall, H, Gibson, OR, Romer, LM, Illidi, C, Hull, JH and Kippelen, P (2021) Systemic but not local rehydration restores dehydration-induced changes in pulmonary function in healthy adults. Journal of Applied Physiology, 130 (3). pp. 517-527. ISSN 8750-7587
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Marshall_JAP_2021_Systemic but not local rehydration restores dehydration-induced changes in pulmonary function in healthy adults.pdf - Published Version Available under License Creative Commons Attribution. Download (729kB) | Preview |
Abstract
Water transport and local (airway) hydration are critical for the normal functioning of lungs and airways. Currently, there is uncertainty regarding the effects of systemic dehydration on pulmonary function. Our aims were 1) to clarify the impact of exercise- or fluid restriction-induced dehydration on pulmonary function in healthy adults; and 2) to establish whether systemic or local rehydration can reverse dehydration-induced alterations in pulmonary function. Ten healthy participants performed four experimental trials in a randomized order (2 h exercise in the heat twice and 28 h fluid restriction twice). Pulmonary function was assessed using spirometry and whole body plethysmography in the euhydrated, dehydrated, and rehydrated states. Oral fluid consumption was used for systemic rehydration and nebulized isotonic saline inhalation for local rehydration. Both exercise and fluid restriction induced mild dehydration (2.7 ± 0.7% and 2.5 ± 0.4% body mass loss, respectively; P < 0.001) and elevated plasma osmolality (P < 0.001). Dehydration across all four trials was accompanied by a reduction in forced vital capacity (152 ± 143 mL, P < 0.01) and concomitant increases in residual volume (216 ± 177 mL, P < 0.01) and functional residual capacity (130 ± 144 mL, P < 0.01), with no statistical differences between modes of dehydration. These changes were normalized by fluid consumption but not nebulization. Our results suggest that, in healthy adults: 1) mild systemic dehydration induced by exercise or fluid restriction leads to pulmonary function impairment, primarily localized to small airways; and 2) systemic, but not local, rehydration reverses these potentially deleterious alterations. NEW & NOTEWORTHY This study demonstrates that, in healthy adults, mild systemic dehydration induced by exercise in the heat or a prolonged period of fluid restriction leads to negative alterations in pulmonary function, primarily localized to small airways. Oral rehydration, but not nebulized isotonic saline, is able to restore pulmonary function in dehydrated individuals. Our findings highlight the importance of maintaining an adequate systemic fluid balance to preserve pulmonary function.
| Item Type: | Article |
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| Uncontrolled Keywords: | Lung; Humans; Dehydration; Fluid Therapy; Exercise; Water-Electrolyte Balance; Adult; airway; dehydration; exercise; fluid; nebulization; Adult; Dehydration; Exercise; Fluid Therapy; Humans; Lung; Water-Electrolyte Balance; 06 Biological Sciences; 11 Medical and Health Sciences; Physiology |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | American Physiological Society |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 28 Aug 2024 11:44 |
| Last Modified: | 28 Aug 2024 11:45 |
| DOI or ID number: | 10.1152/JAPPLPHYSIOL.00311.2020 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/24027 |
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