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Mathew Thevarkattil, A, Yousaf, S, Houacine, C, Khan, W, Bnyan, R, Elhissi, A and Khan, I (2024) Anticancer drug delivery: Investigating the impacts of viscosity on lipid-based formulations for pulmonary targeting. International Journal of Pharmaceutics. ISSN 0378-5173
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Anticancer drug delivery Investigating the impacts of viscosity on lipid-based formulations for pulmonary targeting.pdf - Published Version Available under License Creative Commons Attribution. Download (4MB) | Preview |
Abstract
Pulmonary drug delivery via aerosolization is a non-intrusive method for achieving localized and systemic effects. The aim of this study was to establish the impact of viscosity as a novel aspect (i.e., low, medium and high) using various lipid-based formulations (including liposomes (F1-F3), transfersomes (F4-F6), micelles (F7-F9) and nanostructured lipid carriers (NLCs; F10-F12)) as well as to investigate their impact on in-vitro nebulization performance using Trans-resveratrol (TRES) as a model anticancer drug. Based on the physicochemical properties, micelles (F7-F9) elicited the smallest particle size (12-174 nm); additionally, all formulations tested exhibited high entrapment efficiency (>89 %). Through measurement using capillary viscometers, NLC formulations exhibited the highest viscosity (3.35-10.04 m2/sec). Upon using a rotational rheometer, formulations exhibited shear-thinning (non-Newtonian) behaviour. Air jet and vibrating mesh nebulizers were subsequently employed to assess nebulization performance using an in-vitro model. Higher viscosity formulations elicited a prolonged nebulization time. The vibrating mesh nebulizer exhibited significantly higher emitted dose (ED), fine particle fraction (FPF) and fine particle dose (FPD) (up to 97 %, 90 % and 64 µg). Moreover, the in-vitro release of TRES was higher at pH 5, demonstrating an alignment of the release profile with the Korsmeyer-Peppas model. Thus, formulations with higher viscosity paired with a vibrating mesh nebulizer were an ideal combination for delivering and targeting peripheral lungs.
| Item Type: | Article |
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| Uncontrolled Keywords: | Lipid-based formulations; Nanoparticles; Nebulization performance; Sustained release; Viscosity; 1115 Pharmacology and Pharmaceutical Sciences; Pharmacology & Pharmacy |
| Subjects: | R Medicine > RS Pharmacy and materia medica T Technology > TA Engineering (General). Civil engineering (General) |
| Divisions: | Civil Engineering & Built Environment Pharmacy & Biomolecular Sciences |
| Publisher: | Elsevier |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 30 Aug 2024 11:02 |
| Last Modified: | 30 Aug 2024 11:02 |
| DOI or ID number: | 10.1016/j.ijpharm.2024.124591 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/24041 |
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