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Kazan, HH, Bulgay, C, Zorba, E, Dalip, M, Ceylan, H, Semenova, EA, Larin, AK, Kulemin, NA, Generozov, EV, Ahmetov, II and Cerit, M (2024) Exploring the relationship between caffeine metabolism-related CYP1A2 rs762551 polymorphism and team sport athlete status and training adaptations. Molecular Biology Reports, 51 (1). ISSN 0301-4851
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Exploring the relationship between caffeine metabolism-related CYP1A2 rs762551 polymorphism and team sport athlete status and training adaptations.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Background: This study aimed to achieve a dual objective: to compare the frequencies of CYP1A2 rs762551 genotypes between team sport athletes and a control group, and to determine the association between the rs762551 polymorphism and changes in physical performance after a six-week training program among elite basketball players. Methods: The study encompassed an analysis of 504 individuals, comprising 320 athletes and 184 controls. For the Turkish cohort, DNA was isolated using the buccal swab method, and genotyping was conducted using the KASP technique. Performance assessments included the Yo-Yo IR2 and 30 m sprint tests. For Russian participants, DNA samples were extracted from peripheral blood, a commercial kit was used for DNA extraction, and genotyping of the rs762551 polymorphism was conducted using DNA microarray. Result: Notably, a statistically significant linear decline in the prevalence of the CC genotype was observed with ascending levels of athletic achievement within team sports (sub-elite: 18.0%, elite: 8.2%, highly elite: 0%; p = 0.001). Additionally, the CA genotype was the most prevalent genotype in the highly elite group compared to controls (80.0% vs. 45.1%, p = 0.048). Furthermore, statistically significant improvements in Yo-Yo IR2 performance were noted exclusively among basketball players harboring the CA genotype (p = 0.048). Conclusions: The study’s findings indicate that the rs762551 CC genotype is a disadvantage in elite team sports, whereas the CA genotype provides an advantage in basketball performance.
| Item Type: | Article |
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| Uncontrolled Keywords: | Humans; Caffeine; Cytochrome P-450 CYP1A2; Adaptation, Physiological; Genotype; Polymorphism, Single Nucleotide; Basketball; Adult; Turkey; Female; Male; Athletic Performance; Young Adult; Athletes; Team Sports; Athletic performance; Caffeine; Coffee consumption; Exercise; Metabolism; Supplements; Humans; Male; Cytochrome P-450 CYP1A2; Athletes; Athletic Performance; Caffeine; Polymorphism, Single Nucleotide; Genotype; Young Adult; Female; Adult; Team Sports; Basketball; Adaptation, Physiological; Turkey; 0601 Biochemistry and Cell Biology; Biochemistry & Molecular Biology |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine G Geography. Anthropology. Recreation > GV Recreation Leisure > GV561 Sports |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Springer |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 16 Sep 2024 09:16 |
| Last Modified: | 16 Sep 2024 09:16 |
| DOI or ID number: | 10.1007/s11033-024-09800-2 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/24138 |
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