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Ogiji, ED, Aboheimed, N, Ross, K, Voller, C, Siner, R, Jensen, RL, Jolly, CE and Carr, DF (2024) Greater mechanistic understanding of the cutaneous pathogenesis of Stevens-Johnson syndrome/toxic epidermal necrolysis can shed light on novel therapeutic strategies: a comprehensive review. Current Opinion in Allergy and Clinical Immunology, 24 (4). pp. 218-227. ISSN 1528-4050
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Abstract
Purpose of review Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are severe cutaneous adverse drug reactions (SCARs) characterized by widespread epithelial detachment and blistering, which affects the skin and mucocutaneous membranes. To date, therapeutic interventions for SJS/TEN have focused on systematic suppression of the inflammatory response using high-dose corticosteroids or intravenous immunoglobulin G (IgG), for example. No targeted therapies for SJS/TEN currently exist. Recent findings Though our understanding of the pathogenesis of SJS/TEN has advanced from both an immunological and dermatological perspective, this knowledge is yet to translate into the development of new targeted therapies. Summary Greater mechanistic insight into SJS/TEN would potentially unlock new opportunities for identifying or repurposing targeted therapies to limit or even prevent epidermal injury and blistering.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | drug hypersensitivity; drug repurposing; pathogenesis; Stevens-Johnson syndrome; toxic epidermal necrolysis; drug hypersensitivity; drug repurposing; pathogenesis; Stevens-Johnson syndrome; toxic epidermal necrolysis; Skin; Animals; Humans; Stevens-Johnson Syndrome; Adrenal Cortex Hormones; Immunoglobulins, Intravenous; Molecular Targeted Therapy; Stevens-Johnson Syndrome; Humans; Immunoglobulins, Intravenous; Skin; Adrenal Cortex Hormones; Animals; Molecular Targeted Therapy; 1107 Immunology; Allergy |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | Lippincott, Williams & Wilkins |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 08 Nov 2024 14:13 |
| Last Modified: | 08 Nov 2024 14:15 |
| DOI or ID number: | 10.1097/ACI.0000000000000993 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/24719 |
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