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Tavabie, OD, Enever, Y, Green, D, Crisp, H, Tsochatzis, E, Gander, A, Mansour, D, Hebditch, V, Adams, J, Ashbourn, A, Mysko, C, Allen, R, Kent, L, Maurice, JB, Srivastava, A, Chauhan, A, Johnston, T, Ruane, J, Varni, R, Fletcher, C , Sieberhagen, C, Hay, G, Bretland, G, Corrigan, M, Ferraro, F, Mcmahon, R, Burge, T, Ferguson, H, Jennings, L, Hogan, B, Cook, A, Jalan, R and Mehta, G (2024) From O'Shaughnessy to opportunity: innovating Hepatology Trials in the UK. Frontline Gastroenterology, 15 (5). pp. 395-400. ISSN 2041-4137
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Abstract
Developing new treatments that improve outcomes for patients with decompensated cirrhosis remains an unmet area of clinical need. The UK has a rich history of being on the forefront of clinical trials for this patient group. However, there have been challenges in achieving this goal in the past decade, with several negative studies as well as trials struggling to achieve recruitment. This has been further exacerbated by the changed clinical landscape following the COVID-19 pandemic. In response to this, the O'Shaughnessy report was commissioned to identify potential opportunities to improve clinical trial performance in the UK. In this review article, we identify critical areas for the UK hepatology community to collaborate and develop sustainable partnerships for clinical trial delivery which will ensure that outcomes are representative, inclusive and patient-centred.
| Item Type: | Article |
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| Additional Information: | This article has been accepted for publication in Frontline Gastroenterology, 2024 following peer review, and the Version of Record can be accessed online at https://doi.org/10.1136/flgastro-2024-102710 |
| Uncontrolled Keywords: | Coronaviruses; Clinical Research; Clinical Trials and Supportive Activities; 6.9 Resources and infrastructure (treatment evaluation); 8.4 Research design and methodologies (health services); 3 Good Health and Well Being |
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Public and Allied Health |
| Publisher: | BMJ Publishing Group |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 28 Nov 2024 12:33 |
| Last Modified: | 28 Nov 2024 12:33 |
| DOI or ID number: | 10.1136/flgastro-2024-102710 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/24913 |
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