van der Sluijs, K, Bakker, E, Kerstens, T, Stens, N, de Koning, I, Thannhauser, J, Malik, A, Reesink, K, Nabeel, PM, Raj, K, Joseph, J, Allard, NAE, Berge, K, Bongers, CCWG, Brouwer, CG, Hartman, YAW, Hazeleger, LR, Hopman, MTE, Janssen, SLJE, Janssen Daalen, JM et al, Kersten, BTP, Koopmans, L, Kroesen, SH, Landman, TRJ, Luiken, TTJ, Mast, IH, Peggen, MAG, Schoofs, MCA, Schreurs, BA, Vermeulen, JJM, Vloet, JIA, Wanders, L, Eijsvogels, T and Thijssen, D (2024) Association of Objectively Measured Sedentary Behavior With Arterial Stiffness: Findings From the Nijmegen Exercise Study. Scandinavian Journal of Medicine and Science in Sports, 34 (11). e14757. ISSN 0905-7188

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Abstract

Sedentary behavior (SB) may affect arterial stiffness, preceding the development of cardiovascular disease. We investigated the association of objectively measured SB with arterial stiffness. We also investigated factors that affected this association. We recruited adult volunteers and measured SB with thigh-worn accelerometery for 24 hrs/day for eight consecutive days. Central (carotid-femoral pulse wave velocity, cfPWV, gold standard) and local carotid arterial stiffness (stiffness index Beta and pressure-strain elasticity EP) were measured with ultrasound. Linear regression was used and adjusted for demographics, cardiometabolic factors, and moderate-to-vigorous physical activity (MVPA) volume. Effect modification was studied with interaction terms. Participants (N = 664, 64 (standard deviation: 11, range: 23–89) years, 397 (59.8%) male) demonstrated 9.1 (1.6) hrs/day of SB, and arterial stiffness was 8.6 (3.0) m/s for cfPWV, 6.4 (2.9) for Beta, and 87 (43) kPa for EP. SB was not associated with cfPWV (β = 0.04 95% CI (−0.11, 0.18), p = 0.60). The association of SB with local arterial stiffness was modified by systolic blood pressure (SBP) and MVPA volume. Stratified analyses revealed positive associations of SB with Beta (β = 0.29 (0.05, 0.53), p = 0.016) and EP (β = 4.83 (1.39, 8.27), p = 0.006) in participants with SBP > 134 mmHg or > 103 min/day of MVPA (β = 0.23 (0.03, 0.42), p = 0.024 and β = 3.55 (0.82, 6.29), p = 0.011, respectively). We found no association of objectively measured SB with central arterial stiffness. However, SB was positively associated with local carotid stiffness in participants with higher SBP or MVPA levels. In certain subgroups, SB may affect carotid arterial stiffening, reinforcing the relation between SB and cardiovascular disease.

Item Type:	Article
Uncontrolled Keywords:	Nijmegen Exercise Study collaboration; Humans; Exercise; Cross-Sectional Studies; Blood Pressure; Adult; Aged; Aged, 80 and over; Middle Aged; Netherlands; Female; Male; Young Adult; Vascular Stiffness; Accelerometry; Pulse Wave Analysis; Sedentary Behavior; Carotid-Femoral Pulse Wave Velocity; arterial stiffness; cardiovascular disease; pulse wave velocity; sedentary behavior; thigh‐worn accelerometery; Humans; Vascular Stiffness; Male; Sedentary Behavior; Adult; Middle Aged; Female; Aged; Young Adult; Aged, 80 and over; Blood Pressure; Pulse Wave Analysis; Exercise; Accelerometry; Netherlands; Carotid-Femoral Pulse Wave Velocity; Cross-Sectional Studies; Cardiovascular; Physical Activity; Obesity; Clinical Research; Prevention; Cardiovascular; 3 Good Health and Well Being; Humans; Vascular Stiffness; Male; Sedentary Behavior; Adult; Middle Aged; Female; Aged; Young Adult; Aged, 80 and over; Blood Pressure; Pulse Wave Analysis; Exercise; Accelerometry; Netherlands; Carotid-Femoral Pulse Wave Velocity; Cross-Sectional Studies; 1106 Human Movement and Sports Sciences; 1116 Medical Physiology; Sport Sciences
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport and Exercise Sciences
Publisher:	Wiley
SWORD Depositor:	A Symplectic
Date Deposited:	29 Nov 2024 13:59
Last Modified:	29 Nov 2024 14:00
DOI or ID number:	10.1111/sms.14757
URI:	https://researchonline.ljmu.ac.uk/id/eprint/24947

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