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Gavanji, S, Bakhtari, A, Famurewa, AC and Othman, EM (2023) Cytotoxic Activity of Herbal Medicines as Assessed in Vitro: A Review. Chemistry & Biodiversity, 20 (2). ISSN 1612-1872
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Cytotoxic Activity of Herbal Medicines as Assessed in Vitro A Review.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Since time immemorial, human beings have sought natural medications for treatment of various diseases. Weighty evidence demonstrates the use of chemical methodologies for sensitive evaluation of cytotoxic potentials of herbal agents. However, due to the ubiquitous use of cytotoxicity methods, there is a need for providing updated guidance for the design and development of in vitro assessment. The aim of this review is to provide practical guidance on common cell-based assays for suitable assessment of cytotoxicity potential of herbal medicines and discussing their advantages and disadvantages Relevant articles in authentic databases, including PubMed, Web of Science, Science Direct, Scopus, Google Scholar and SID, from 1950 to 2022 were collected according to selection criteria of in vitro cytotoxicity assays and protocols. In addition, the link between cytotoxicity assay selection and different factors such as the drug solvent, concentration and exposure duration were discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans; Plants, Medicinal; Plant Extracts; Antineoplastic Agents; cytotoxicity; herbal medicines; in vitro; protocol; techniques; Humans; Plants, Medicinal; Antineoplastic Agents; Plant Extracts; Generic health relevance; Humans; Plants, Medicinal; Antineoplastic Agents; Plant Extracts; 0304 Medicinal and Biomolecular Chemistry; 0305 Organic Chemistry; Medicinal & Biomolecular Chemistry |
| Subjects: | R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | Wiley |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 02 Dec 2024 13:56 |
| Last Modified: | 02 Dec 2024 14:00 |
| DOI or ID number: | 10.1002/cbdv.202201098 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/24971 |
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