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Greeny, A, Nair, A, Sadanandan, P, Satarker, S, Famurewa, AC and Nampoothiri, M (2024) Epigenetic Alterations in Alzheimer's Disease: Impact on Insulin Signaling and Advanced Drug Delivery Systems. Biology, 13 (3). ISSN 2079-7737
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Epigenetic Alterations in Alzheimers Disease Impact on Insulin Signaling and Advanced Drug Delivery Systems.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Alzheimer's disease (AD) is a neurodegenerative condition that predominantly affects the hippocampus and the entorhinal complex, leading to memory lapse and cognitive impairment. This can have a negative impact on an individual's behavior, speech, and ability to navigate their surroundings. AD is one of the principal causes of dementia. One of the most accepted theories in AD, the amyloid β (Aβ) hypothesis, assumes that the buildup of the peptide Aβ is the root cause of AD. Impaired insulin signaling in the periphery and central nervous system has been considered to have an effect on the pathophysiology of AD. Further, researchers have shifted their focus to epigenetic mechanisms that are responsible for dysregulating major biochemical pathways and intracellular signaling processes responsible for directly or indirectly causing AD. The prime epigenetic mechanisms encompass DNA methylation, histone modifications, and non-coding RNA, and are majorly responsible for impairing insulin signaling both centrally and peripherally, thus leading to AD. In this review, we provide insights into the major epigenetic mechanisms involved in causing AD, such as DNA methylation and histone deacetylation. We decipher how the mechanisms alter peripheral insulin signaling and brain insulin signaling, leading to AD pathophysiology. In addition, this review also discusses the need for newer drug delivery systems for the targeted delivery of epigenetic drugs and explores targeted drug delivery systems such as nanoparticles, vesicular systems, networks, and other nano formulations in AD. Further, this review also sheds light on the future approaches used for epigenetic drug delivery.
| Item Type: | Article |
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| Uncontrolled Keywords: | Alzheimer’s disease; DNA methylation; drug delivery; histone deacetylase; insulin signaling; pigenetics; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease; Acquired Cognitive Impairment; Dementia; Neurodegenerative; Genetics; Neurosciences; Nanotechnology; Bioengineering; Behavioral and Social Science; Brain Disorders; Aging; Biotechnology; 2.1 Biological and endogenous factors; Neurological; 06 Biological Sciences |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | MDPI AG |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 02 Dec 2024 14:01 |
| Last Modified: | 02 Dec 2024 14:15 |
| DOI or ID number: | 10.3390/biology13030157 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/24972 |
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