Bie, C, Ma, Y, van Zijl, P.C.M., Yadav, N.N., Xu, X, Zheng, H, Liang, D, Zou, C, Areta, JL, Chen, L and Zhou, Y In vivo imaging of glycogen in human muscle. Nature Communications. ISSN 2041-1723 (Accepted)

Preview

Text MainManuscript_NC_R3.pdf - Accepted Version Download (32MB) | Preview

Abstract

Probing regional glycogen metabolism in humans non-invasively has been challenging due to a lack of sensitive approaches. Here we studied human muscle glycogen dynamics post-exercise with a spatial resolution of millimeters and temporal resolution of minutes, using relayed nuclear Overhauser effect (glycoNOE) MRI. Data at 5T showed a homogeneous distribution of glycogen in resting muscle, with an average concentration of 99 ± 13 mM. After plantar flexion exercise following fasting with recovery under fasting conditions, the calf muscle showed spatially heterogeneous glycogen depletion and repletion kinetics that correlated with the severity of this depletion. Three types of regional glycogen kinetics were observed: (i) single exponential repletion (type a); (ii) biphasic recovery of rapid repletion followed by additional depletion (type b); (iii) biphasic recovery where continued depletion is followed by an exponential recovery (type c). The study of the complex patterns of glycogen kinetics suggests that glycogen breakdown may be quantitatively important during the initial recovery.

Item Type:	Article
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport and Exercise Sciences
Publisher:	Nature Portfolio
SWORD Depositor:	A Symplectic
Date Deposited:	18 Dec 2024 10:14
Last Modified:	18 Dec 2024 10:15
URI:	https://researchonline.ljmu.ac.uk/id/eprint/25122

View Item