Selvakumar, SC, Preethi, KA, Ross, K and Sekar, D (2024) The emerging role of microRNA-based therapeutics in the treatment of preeclampsia. Placenta, 158. pp. 38-47. ISSN 0143-4004

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Abstract

Preeclampsia (PE) is a pregnancy complication that is often diagnosed due to elevated blood pressure and proteinuria. Though current research focuses on the identification of novel biomarkers and therapeutic targets, still, there is a lack of clinical validation for the use of biomarkers and therapeutic targets for early diagnosis and treatment of PE. Several molecules are being studied for their potential role in PE. Among them, microRNAs are studied vastly for their role in the diagnosis, prognosis, and treatment of PE. But only a few studies are focused on the therapeutic efficacy of miRNAs in PE. Thus, the relevant articles were identified and discussed in this review. These studies provide evidence that miRNAs are indeed important molecules in PE that have the role of both therapeutic targets and therapeutic molecules. However, the studies are limited to in vivo an in vitro models, hence further studies are required to validate the complete potential of miRNA therapeutics. Long non-coding RNA (lncRNA) sponges, miRNA mimics, miRNA inhibitors, exosome-associated miRNAs, and several other molecules have been studied as miRNA-based therapeutics in PE. Thus, miRNAs are postulated to be potential therapeutic targets and miRNA-based therapeutics might pave the way for novel therapeutic approaches for PE.

Item Type:	Article
Uncontrolled Keywords:	MicroRNAs; Preeclampsia; Therapeutic targets; Vascular remodeling; microRNA-based therapeutics; Animals; Female; Humans; Pregnancy; Biomarkers; MicroRNAs; Pre-Eclampsia; Hypertension; Contraception/Reproduction; Cardiovascular; Genetics; Biotechnology; 5.1 Pharmaceuticals; 2.1 Biological and endogenous factors; 4.1 Discovery and preclinical testing of markers and technologies; Animals; Female; Humans; Pregnancy; Biomarkers; MicroRNAs; Pre-Eclampsia; 0601 Biochemistry and Cell Biology; 1103 Clinical Sciences; 1114 Paediatrics and Reproductive Medicine; Obstetrics & Reproductive Medicine
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics R Medicine > RG Gynecology and obstetrics
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Elsevier
SWORD Depositor:	A Symplectic
Date Deposited:	27 Jan 2025 10:27
Last Modified:	27 Jan 2025 10:30
DOI or ID number:	10.1016/j.placenta.2024.09.018
URI:	https://researchonline.ljmu.ac.uk/id/eprint/25259

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