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Rahimi, MR, Faraji, H, Hajipoor, SR and Ahmetov, II (2024) Effect of MCT1 A1470T Polymorphism on Lactate and Potassium Concentrations After Caffeine Ingestion During Acute Resistance Exercise. Nutrients, 16 (24). pp. 1-12. ISSN 2072-6643
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Effect of MCT1 A1470T Polymorphism on Lactate and Potassium Concentrations After Caffeine Ingestion During Acute Resistance Exercise.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Background: The monocarboxylate transporter 1 (MCT1) plays a crucial role in regulating lactate and pyruvate transport across cell membranes, which is essential for energy metabolism during exercise. The MCT1 A1470T (rs1049434) polymorphism has been suggested to influence lactate transport, with the T (major) allele associated with greater transport efficiency. This study aimed to investigate the effect of the MCT1 polymorphism on lactate and potassium (K+) concentrations in response to resistance exercise (RE) following caffeine (CAF) ingestion. Methods: Thirty resistance-trained athletes were randomly selected to participate in a randomized, double-blind, placebo-controlled crossover study. Participants consumed either CAF (6 mg/kg of body weight) or a placebo (PL; 6 mg of maltodextrin per kg of body weight) one hour before performing RE. Serum lactate and potassium concentrations were measured before exercise (Pre), immediately after (Post), and 15 min post-exercise (15 min Post). The RE protocol consisted of three sets to failure at 85% of 1RM for each exercise, with 2 min rest intervals between sets. Results: The findings indicate that under caffeine consumption, individuals carrying the A (minor) allele had significantly higher blood lactate levels before (p = 0.037) and immediately after (p = 0.0001) resistance exercise compared to those with the TT genotype. Additionally, caffeine consumption moderated the increase in plasma potassium levels in TT genotype carriers, while A allele carriers exhibited elevated potassium levels 15 min post-exercise, regardless of caffeine or placebo intake (p < 0.05). Conclusions: Our findings suggest that the MCT1 A1470T polymorphism may influence lactate metabolism and clearance under caffeine consumption, potentially impacting exercise performance and recovery.
| Item Type: | Article |
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| Uncontrolled Keywords: | DNA; genotype; nutrigenetics; monocarboxylate transporter 1; sports; recovery; resistance exercise; caffeine; lactate; DNA; caffeine; genotype; lactate; monocarboxylate transporter 1; nutrigenetics; recovery; resistance exercise; sports; Humans; Caffeine; Monocarboxylic Acid Transporters; Symporters; Male; Lactic Acid; Double-Blind Method; Cross-Over Studies; Resistance Training; Young Adult; Potassium; Adult; Female; Polymorphism, Single Nucleotide; Polymorphism, Genetic; Athletes; Exercise; Genotype; Alleles; Nutrition; Genetics; Physical Activity; Clinical Research; Clinical Trials and Supportive Activities; 6.1 Pharmaceuticals; 0908 Food Sciences; 1111 Nutrition and Dietetics |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport and Exercise Sciences |
| Publisher: | MDPI |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 17 Jan 2025 10:17 |
| Last Modified: | 17 Jan 2025 10:30 |
| DOI or ID number: | 10.3390/nu16244396 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/25305 |
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