Egorova, ES, Aseyan, KK, Bikbova, ER, Zhilina, AE, Valeeva, EV and Ahmetov, II (2024) Effects of Gene–Lifestyle Interaction on Obesity Among Students. Genes, 15 (12). pp. 1-13. ISSN 2073-4425

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Abstract

Background: Obesity is a global health issue influenced primarily by genetic variants and environmental factors. This study aimed to examine the relationship between genetic and lifestyle factors and their interaction with obesity risk among university students. Methods: A total of 658 students from the same university participated in this study, including 531 females (mean age (SD): 21.6 (3.9) years) and 127 males (21.9 (4.6) years). Among them, 550 were classified as normal weight or underweight (456 females and 94 males), while 108 were identified as overweight or obese (75 females and 33 males). All the participants underwent anthropometric and genetic screening and completed lifestyle and sleep quality questionnaires. Results: The polygenic risk score, based on seven genetic variants (ADCY3 rs11676272, CLOCK rs1801260, GPR61 rs41279738, FTO rs1421085, RP11-775H9.2 rs1296328, SLC22A3 rs9364554, and TFAP2B rs734597), explained 8.3% (p < 0.0001) of the variance in body mass index (BMI). On the other hand, lifestyle factors—such as meal frequency, frequency of overeating, nut consumption as a snack, eating without hunger, frequency of antibiotic use in the past year, symptoms of dysbiosis, years of physical activity, sleep duration, bedtime, ground coffee consumption frequency, and evening coffee consumption time—accounted for 7.8% (p < 0.0001) of the variance in BMI. The model based on gene–environment interactions contributed 15% (p < 0.0001) to BMI variance. Conclusions: This study revealed that individuals with a higher genetic predisposition, as defined by the seven polymorphic loci, are more susceptible to becoming overweight or obese under certain lifestyle conditions.

Item Type:	Article
Uncontrolled Keywords:	lifestyle genetics; DNA; polymorphism; genotype; GxE; gene-lifestyle interaction; obesity; nutrition; eating behavior; DNA; GxE; eating behavior; gene–lifestyle interaction; genotype; lifestyle genetics; nutrition; obesity; polymorphism; Humans; Female; Male; Obesity; Students; Life Style; Young Adult; Adult; Body Mass Index; Genetic Predisposition to Disease; Polymorphism, Single Nucleotide; Adolescent; Gene-Environment Interaction; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Nutrition; Genetics; Obesity; Clinical Research; Basic Behavioral and Social Science; Human Genome; Prevention; Sleep Research; Women's Health; Behavioral and Social Science; 2.1 Biological and endogenous factors; 0604 Genetics
Subjects:	B Philosophy. Psychology. Religion > BF Psychology T Technology > TX Home economics > TX341 Nutrition. Foods and food supply Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport and Exercise Sciences
Publisher:	MDPI
SWORD Depositor:	A Symplectic
Date Deposited:	17 Jan 2025 10:40
Last Modified:	17 Jan 2025 10:45
DOI or ID number:	10.3390/genes15121506
URI:	https://researchonline.ljmu.ac.uk/id/eprint/25307

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