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Mainas, G, Ozgu, I, Sari, A, Vinciguerra, M, Ide, M, Ayakta, BB, Ustun, K and Nibali, L (2025) The application of a Fasting-mimicking Diet in Periodontitis. A feasibility study. Journal of Dentistry. ISSN 0300-5712
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Abstract
Objectives The aim of this study was to test the feasibility of a fasting mimicking diet on the systemic and periodontal response following non-surgical periodontal therapy. Methods Twenty patients with periodontitis were randomized to receive steps 1 and 2 of periodontal treatment alone (following their normal diet) or with an adjunctive 5-day course of fasting-mimicking diet (FMD). Blood and gingival crevicular fluid (GCF) samples were collected to study the levels of inflammatory biomarkers, along with clinical parameters and patients reported outcome measurements (PROMs). All patients were followed up at day-1, day-7 and 3 months post-treatment and food diaries were completed to assess their compliance. Results Nineteen patients completed the 3-months follow-up. Only minimal adverse events including nausea, fatigue, weakness and dizziness were reported in the test group, with no differences in PROMs between groups. Test patients exhibited a non-statistically significant 3-months serum hs-CRP reduction of 0.20 ± 0.30 mg/l compared with 0.11 ± 0.52 mg/l in controls (p=0.632) and a trend for lower GCF levels of MMP-8, IL-6 and IL-1B post-treatment compared with controls. Conclusions This study suggests that one cycle of adjunctive FMD is feasible and may modulate the inflammatory response post-non-surgical periodontal therapy. Larger studies are needed to test this hypothesis. (clinicaltrials.gov ID: NCT05684627).
| Item Type: | Article |
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| Uncontrolled Keywords: | Diet; Fasting; Gingival Crevicular Fluid; Periodontitis; Serum; 32 Biomedical and Clinical Sciences; 3203 Dentistry; Nutrition; Infectious Diseases; Clinical Research; Dental/Oral and Craniofacial Disease; Clinical Trials and Supportive Activities; 6.1 Pharmaceuticals; Oral and gastrointestinal; 1105 Dentistry; Dentistry; 3203 Dentistry |
| Subjects: | R Medicine > RK Dentistry R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | Elsevier BV |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 04 Mar 2025 09:19 |
| Last Modified: | 04 Mar 2025 09:30 |
| DOI or ID number: | 10.1016/j.jdent.2025.105644 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/25773 |
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