Genomic predictors of fat mass response to the standardized exercise training

Yang, X, Li, Y, Bao, D, Yan, B, Mei, T, Liu, X, Cięszczyk, P, Ahmetov, II, Mc Naughton, LR and He, Z (2024) Genomic predictors of fat mass response to the standardized exercise training. International Journal of Sports Medicine, 46 (2). pp. 127-136. ISSN 0172-4622

Preview

Text Genomic predictors of fat mass response to the standardized exercise training.pdf - Accepted Version Download (1MB) | Preview

Abstract

To explore the genetic architecture underlying exercise-induced fat mass change, we performed a genome-wide association study with a Chinese cohort consisting of 442 physically inactive healthy adults in response to a 12-week exercise training (High-intensity Interval Training or Resistance Training). The inter-individual response showed an exercise-induced fat mass change and ten novel lead SNPs were associated with the response on the level of P<1×10 -5. Four of them (rs7187742, rs1467243, rs28629770 and rs10848501) showed a consistent effect direction in the European ancestry. The Polygenic Predictor Score (PPS) derived from ten lead SNPs, sex, baseline body mass and exercise protocols explained 40.3% of the variance in fat mass response, meanwhile importantly the PPS had the greatest contribution. Of note, the subjects whose PPS was lower than -9.301 had the highest response in exercise-induced fat loss. Finally, we highlight a series of pathways and biological processes regarding the fat mass response to exercise, e.g. apelin signaling pathway, insulin secretion pathway and fat cell differentiation biological process.

Item Type:	Article
Additional Information:	© 2024. Thieme. All rights reserved.
Uncontrolled Keywords:	Adipose Tissue; Humans; Insulin; Polymorphism, Single Nucleotide; Adult; Female; Male; Resistance Training; Genome-Wide Association Study; Young Adult; High-Intensity Interval Training; Apelin; Asian People; Humans; Male; Female; Genome-Wide Association Study; Polymorphism, Single Nucleotide; Adult; Resistance Training; High-Intensity Interval Training; Apelin; Adipose Tissue; Insulin; Asian People; Young Adult; 42 Health Sciences; 4207 Sports Science and Exercise; Genetics; Nutrition; Prevention; Physical Activity; Behavioral and Social Science; Human Genome; 2.1 Biological and endogenous factors; Humans; Male; Female; Genome-Wide Association Study; Polymorphism, Single Nucleotide; Adult; Resistance Training; High-Intensity Interval Training; Apelin; Adipose Tissue; Insulin; Asian People; Young Adult; 0913 Mechanical Engineering; 1106 Human Movement and Sports Sciences; Sport Sciences; 4207 Sports science and exercise
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport and Exercise Sciences
Publisher:	Thieme Gruppe |
Date of acceptance:	18 September 2024
Date of first compliant Open Access:	30 October 2025
Date Deposited:	06 Mar 2025 16:11
Last Modified:	30 Oct 2025 08:00
DOI or ID number:	10.1055/a-2421-9385
URI:	https://researchonline.ljmu.ac.uk/id/eprint/25811

View Item