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van der Sluijs, KM, Vloet, JIA, Thijssen, DHJ, Eijsvogels, TMH and Bakker, EA Cardiometabolic Benefit of Replacing Sedentary Time with Light-Intensity Physical Activity: Compositional Data Analysis of the Nijmegen Exercise Study. Medicine and Science in Sports and Exercise. ISSN 0195-9131 (Accepted)
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Cardiometabolic Benefit of Replacing Sedentary Time with Light-Intensity Physical Activity Compositional Data Analysis of the Nijmegen Exercise Study.pdf - Accepted Version Available under License Creative Commons Attribution. Download (4MB) | Preview |
Abstract
Purpose: The cardiometabolic benefits of replacing sedentary time with light-intensity physical activity (LIPA) are unclear. We studied the associations of hypothetically reallocating sedentary time towards LIPA with changes in cardiometabolic risk factors using thigh-worn accelerometery. We also explored whether reallocation effects differed across subgroups with low, moderate, and high sedentary time and compared proportionally similar reallocations to either LIPA or moderate-to-vigorous physical activity (MVPA). Methods: We assessed physical behaviours across eight consecutive days using thigh-worn accelerometers among adults from the Nijmegen Exercise Study. Multiple cardiometabolic risk factors were assessed and categorised as: 1) anthropometrics, 2) cardiovascular biomarkers, and 3) glucose metabolism. Reallocation effects were estimated for each cardiometabolic risk factor using compositional isotemporal substitution models adjusted for confounders. Analyses were repeated in sedentary time subgroups, i.e. <8.5, 8.5-10, and >10 hours/day. Results: We included 1,041 participants (64 (standard deviation 11) years; 39.5% female). Reallocating sedentary time towards LIPA was associated with improvements in anthropometrics, some cardiovascular biomarkers, and glucose metabolism; e.g., replacing 60 minutes/day of sedentary time with LIPA was associated with improvements in BMI (-0.28 (-0.42, -0.13) kg/m2), eGFR (0.68 (0.15, 1.20) mL/min/1.73m2), and glucose (-0.05 (-0.08, -0.03) mmol/L). Trends suggested that reallocation benefits were strongest in those with >8.5 hours/day of sedentary time. Proportionally similar replacements of sedentary time with either LIPA or MVPA were associated with similar cardiometabolic benefits. Conclusions: Reallocation of sedentary time to LIPA was associated with improvements in cardiometabolic risk factors, predominantly in anthropometrics and glucose metabolism, with greater benefits in the most sedentary individuals. Time reallocation from sedentary time to LIPA may be an effective and arguably feasible strategy to improve population-wide cardiometabolic health.
| Item Type: | Article |
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| Uncontrolled Keywords: | Nijmegen Exercise Study Collaboration; 32 Biomedical and Clinical Sciences; 4206 Public Health; 42 Health Sciences; 3202 Clinical Sciences; Minority Health; Cardiovascular; Clinical Research; Physical Activity; Obesity; Prevention; Nutrition; Cardiovascular; Metabolic and endocrine; 1106 Human Movement and Sports Sciences; 1116 Medical Physiology; 1117 Public Health and Health Services; Sport Sciences; 3202 Clinical sciences; 3208 Medical physiology; 4207 Sports science and exercise |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport and Exercise Sciences |
| Publisher: | Ovid Technologies (Wolters Kluwer Health) |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 08 Apr 2025 11:30 |
| Last Modified: | 08 Apr 2025 11:30 |
| DOI or ID number: | 10.1249/MSS.0000000000003705 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/26117 |
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