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Mantle, D and Hargreaves, I (2025) Coenzyme Q10 and the Blood–Brain Barrier: An Overview. Journal of Clinical Medicine, 14 (8). p. 2748.
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Abstract
Mitochondrial dysfunction is a common factor known to be involved in the pathogenesis of a number of neurological disorders, including Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis. Given the importance of coenzyme Q10 (CoQ10) in promoting normal mitochondrial function, and the deficiency of CoQ10 reported in such neurological disorders, there is a rationale for investigating the potential therapeutic role of supplementary CoQ10. However, while there is evidence for the efficacy of CoQ10 supplementation in animal models of the above disorders, randomised controlled clinical trials supplementing CoQ10 in PD, AD, or ALS have had disappointing outcomes. This in turn may be a reflection of the current uncertainty as to whether CoQ10 can access the blood–brain barrier in human subjects. In an attempt to further elucidate the disparity in outcomes of such preclinical and clinical studies, in this article we have reviewed evidence from the peer-reviewed literature to establish the ability of CoQ10 to access the brain via the BBB.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1103 Clinical Sciences; 32 Biomedical and clinical sciences |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | MDPI |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 17 Apr 2025 13:17 |
| Last Modified: | 17 Apr 2025 13:17 |
| DOI or ID number: | 10.3390/jcm14082748 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/26216 |
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