A Comprehensive Review of Large-Scale Extraction and Purification of Food-Derived Bioactive Phenolic Components

Shawky, E, Nahar, L, Nassief, SM, Sarker, S and Ibrahim, RS (2025) A Comprehensive Review of Large-Scale Extraction and Purification of Food-Derived Bioactive Phenolic Components. Process Biochemistry. ISSN 1359-5113

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Abstract

As the market for functional foods and nutraceuticals grows, traditional extraction methods often fall short of meeting large-scale production needs. This review analyzes recent advancements in large-scale extraction and purification methods for phenolic compounds, addressing the industrial demand for high-quality phenolic-rich products. It explores innovative technologies such as ultrasound-assisted extraction, microwave-assisted extraction, and pressurized liquid extraction. The challenges of scaling these technologies from laboratory to industrial scale are discussed, including maintaining bioactivity, optimizing process parameters, and ensuring cost-effectiveness. The review also covers advanced purification techniques like membrane filtration, adsorption processes, and advanced chromatographic methods. Additionally, the review highlights the environmental and economic aspects of large-scale phenolic extraction, emphasizing sustainable practices, such as eco-friendly solvents and waste valorization. It provides insights into the latest trends in process design and optimization, including computational modeling and process intensification strategies. Finally, the review identifies key areas for future research and development.

Item Type:	Article
Uncontrolled Keywords:	0601 Biochemistry and Cell Biology; Biotechnology; 3101 Biochemistry and cell biology; 3106 Industrial biotechnology
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Elsevier
Date of acceptance:	28 April 2025
Date Deposited:	29 Apr 2025 14:43
Last Modified:	29 Apr 2025 14:43
DOI or ID number:	10.1016/j.procbio.2025.04.027
URI:	https://researchonline.ljmu.ac.uk/id/eprint/26283

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