A review of food hydrocolloids on cardiovascular health: Alginate, astragalus polysaccharides, carrageenan, fucoidan, lunasin, and psyllium

Pandey, AK, Ezewudo, E, Hoque, N, Pandey, AT, Menon, S, Simon, N, Rasouli, B, Habibi, E, Sarker, S, Nahar, L and Hasan, R A review of food hydrocolloids on cardiovascular health: Alginate, astragalus polysaccharides, carrageenan, fucoidan, lunasin, and psyllium. International Journal of Biological Macromolecules. ISSN 0141-8130 (Accepted)

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Abstract

Food hydrocolloids, derived from natural sources such as plants, algae, and microbes, possess bioactive properties that significantly contribute to cardiovascular health. This review focuses on six key hydrocolloids: alginate, astragalus polysaccharides, carrageenan, fucoidan, lunasin, and psyllium, while also considering other important natural hydrocoloids such as short chain fatty acids (SCFAs), plant-derived food hydrocolloids, plant-derived gums, plant-derived mucilages, pectin, modified citrus pectin, inulin, naringenin, chia seeds, gelatine, whey protein, casein, microbial exopolysaccharides and gums, ulvan, and laminarin. Alginate, from brown seaweed, aids in cardiac tissue regeneration and repair. Astragalus polysaccharides, from the Astragalus plant, provide antioxidant, anti-inflammatory, and immunomodulatory benefits. Carrageenan, sourced from red seaweed, supports lipid profile balance and heart health. Fucoidan, another brown seaweed derivative, offers antihypertensive and lipid-lowering effects. Lunasin, a peptide found in soybeans, oats, and barley, is known for its cholesterol-lowering properties and anti-inflammatory effects. Psyllium, rich in soluble fiber, helps lower LDL cholesterol and improve overall cardiovascular function. These hydrocolloids, along with other mentioned compounds, are utilized in drug formulations, cosmetics, processed foods, and dietary supplements, enhancing food texture and stability while delivering health benefits. Upon consumption, they can be absorbed into the bloodstream or metabolized by gut microbiota into bioactive metabolites. This review examines their effects on cardiovascular function, highlighting their mechanisms in regulating vascular tone, blood pressure, vascular inflammation, and cardiac function. It consolidates current research, emphasizing the potential of these hydrocolloids and related compounds in the prevention and management of cardiovascular diseases (CVDs).

Item Type:	Article
Uncontrolled Keywords:	0601 Biochemistry and Cell Biology; Polymers; 3101 Biochemistry and cell biology
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Elsevier
Date of acceptance:	19 May 2025
Date Deposited:	22 May 2025 15:21
Last Modified:	22 May 2025 15:30
URI:	https://researchonline.ljmu.ac.uk/id/eprint/26399

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