Export Citation
Export Citation
Mantle, D, Dewsbury, M, Mendelow, A.D. and Hargreaves, I (2025) Traumatic Brain Injury and Coenzyme Q10: An Overview. International Journal of Molecular Sciences, 26 (11). ISSN 1661-6596
Preview |
Text
ijms-26-05126.pdf - Published Version Available under License Creative Commons Attribution. Download (608kB) | Preview |
Abstract
The incidence of morbidity and mortality in patients who have suffered traumatic brain injury (TBI) is such that novel therapeutic strategies are currently required. There is good evidence that ischaemia is the primary, and sometimes the secondary, cause of brain damage in TBI. This ischaemia may lead to mitochondrial dysfunction, with associated oxidative stress and inflammation, in the pathogenesis of brain injury following head trauma. This, in turn, provides a rationale for the use of supplemental coenzyme Q10 (CoQ10) in the management of TBI, given its key roles in normal mitochondrial function and as an antioxidant and anti-inflammatory agent. In this article, we, therefore, review the use of supplemental CoQ10 in animal models of TBI and its potential application in the management of TBI patients. The problem of blood–brain barrier access is discussed, and how this might be circumvented via the use of an intranasal route to provide direct access of CoQ10 to the brain. In addition, there is evidence that TBI patients have an increased risk of developing cardiac dysfunction and that this may be mediated by aberrant immune action. Given the role of CoQ10 in promoting normal cardiac function and normal immune function, the administration of CoQ10 to prevent cardiovascular complications may improve outcomes in TBI patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 0399 Other Chemical Sciences; 0604 Genetics; 0699 Other Biological Sciences; Chemical Physics; 3101 Biochemistry and cell biology; 3107 Microbiology; 3404 Medicinal and biomolecular chemistry |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | MDPI |
| Date of acceptance: | 23 May 2025 |
| Date of first compliant Open Access: | 27 May 2025 |
| Date Deposited: | 27 May 2025 10:05 |
| Last Modified: | 27 May 2025 10:15 |
| DOI or ID number: | 10.3390/ijms26115126 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/26420 |
 |
View Item |