Interventions to improve access to opioid agonist therapy in acute hospitals: A scoping review

Lewer, D, Tilouche, N, Bradbury, M, Brothers, TD, Holland, A, Hope, V, Gittins, R, Scott, J, Searle, K, Watson, G and Harris, M (2025) Interventions to improve access to opioid agonist therapy in acute hospitals: A scoping review. PLOS Mental Health, 2 (5).

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Abstract

Many people who use illicit opioids have negative experiences when admitted to hospital, which is partly due to poor availability of opioid agonist therapy (OAT). We conducted a scoping review of interventions to increase access OAT to for hospital patients, with searches of MEDLINE, EMBASE, PsychINFO, and CINAHL for evaluations published before 29 July 2024. We followed a registered protocol (identifier: CRD42022313237). We included interventions in acute inpatient or emergency department settings, and extracted intervention characteristics, location, evaluation design and quality, and evidence for effectiveness. We included 57 studies; 50 from the United States, six from Canada, and one from the UK. Fifty-one were published in 2015 or later. We identified three intervention classes: (a) pathways to initiate OAT in emergency departments, entailing screening patients or training staff to identify withdrawal, initiating buprenorphine, and supported referrals (26 studies); (b) multidisciplinary ‘addiction consult teams’, which provide substance-related care across hospital departments, advise primary medical teams on issues such as pain relief and withdrawal management, and support patients with discharge and onward care (18 studies); and (c) Interventions that build capacity of general clinical teams to provide OAT to inpatients, including protocols to identify patients who need OAT, multidisciplinary patient review, and training/clinical education (13 studies). Most interventions included multiple components, and the most common were clinical education and measures to improve continuity of OAT after discharge, such as bridge prescriptions and supported referrals to community prescribers. Almost all studies concluded that interventions were effective, however evaluation methods were generally weak and most used before/after or case series designs. Efforts to improve OAT in acute hospitals emerged recently in North America and focus on addiction consult teams and initiation of buprenorphine in emergency departments. Although formal evaluation is weak, these models may represent starting points for national policy and larger research programmes.

Item Type:	Article
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:	Public and Allied Health
Publisher:	Public Library of Science (PLoS)
Date of acceptance:	30 April 2025
Date of first compliant Open Access:	3 June 2025
Date Deposited:	03 Jun 2025 14:38
Last Modified:	03 Jun 2025 15:00
DOI or ID number:	10.1371/journal.pmen.0000322
Editors:	Morin, KA
URI:	https://researchonline.ljmu.ac.uk/id/eprint/26509

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