Effects of Sleep Deprivation on Physical and Mental Health Outcomes: An Umbrella Review

Shah, AS, Pant, MR, Bommasamudram, T, Nayak, KR, Roberts, SSH, Gallagher, C ORCID: 0000-0002-0712-4482, Vaishali, K, Edwards, BJ ORCID: 0000-0001-8913-0941, Tod, D, Davis, F and Pullinger, SA (2025) Effects of Sleep Deprivation on Physical and Mental Health Outcomes: An Umbrella Review. American Journal of Lifestyle Medicine. ISSN 1559-8276

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Abstract

The increasing prevalence of reduced habitual sleep duration presents a significant public health challenge, impacting cardiovascular health, metabolic function and mental well-being. This umbrella review analyses findings from systematic reviews and meta-analyses to comprehensively evaluate the consequences of sleep deprivation (SD) on health. The databases searched included PubMed, Scopus, and Web of Science. Inclusion criteria focused on adult populations with SD and systematic reviews/meta-analyses. Twenty-nine articles were included in the final synthesis, encompassing a variety of health outcomes. Key findings highlight a U-shaped relationship between sleep duration and all-cause mortality, with both short (<7 h) sleep durations associated with increased risks. SD was a significant risk factor for cardiovascular diseases such as hypertension, stroke and coronary heart disease. Alongside heightened risks of metabolic disorders, like obesity and type 2 diabetes. Moreover, SD contributed to elevated anxiety levels, impaired emotional regulation. As well as increased susceptibility to stress and depressive symptoms. This synthesis underscores the critical importance of maintaining recommended sleep duration (typically 7-9 h for adults) to mitigate these health risks effectively. The findings support the need for robust public health interventions aimed at promoting healthy sleep habits to reduce the burden of associated health conditions and enhance overall well-being.

Item Type:	Article
Uncontrolled Keywords:	4203 Health Services and Systems; 32 Biomedical and Clinical Sciences; 4206 Public Health; 42 Health Sciences; Aging; Sleep Research; Clinical Research; Heart Disease; Mental Illness; Cardiovascular; Mental Health; Brain Disorders; Depression; Prevention; Behavioral and Social Science; Obesity; 6.1 Pharmaceuticals; Mental health; Cardiovascular; 3 Good Health and Well Being; 1111 Nutrition and Dietetics; 1117 Public Health and Health Services; 3210 Nutrition and dietetics; 4206 Public health
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport and Exercise Sciences
Publisher:	SAGE Publications
Date of acceptance:	16 May 2025
Date of first compliant Open Access:	9 July 2025
Date Deposited:	09 Jul 2025 13:21
Last Modified:	09 Jul 2025 13:30
DOI or ID number:	10.1177/15598276251346752
URI:	https://researchonline.ljmu.ac.uk/id/eprint/26748

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