Correcting hypophosphataemia in a paediatric patient with Sanjad-Sakati syndrome through a single oral dose of potassium phosphate intravenous solution

Sabti, MA and Shamsaldeen, YA (2021) Correcting hypophosphataemia in a paediatric patient with Sanjad-Sakati syndrome through a single oral dose of potassium phosphate intravenous solution. SAGE Open Medical Case Reports, 9. pp. 1-4. ISSN 2050-313X

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Abstract

Sanjad-Sakati syndrome is an autosomal recessive disorder that is quite common in Kuwait. Among a wide range of complications in Sanjad-Sakati syndrome patients is the vulnerability to infections and subsequent hypophosphataemia. Hypophosphataemia is a metabolic alteration that contributes to numerous consequences such as cardiac arrhythmia. Therefore, if hypophosphataemia is left unresolved, it may culminate in death. A 20-month-old boy of 2.5 kg body weight diagnosed with Sanjad-Sakati syndrome was initially admitted to the paediatric intensive care unit after recovering from COVID-19, and then shifted to the general ward. He was diagnosed with recurrent pneumonia and urinary tract infection. After 9 days, the patient showed severe hypophosphataemia with serum phosphate concentration reaching 0.33 mmol/L. Despite the availability of potassium phosphate intravenous solution, it was difficult to administer potassium phosphate intravenously because of the small body size and low body weight of the patient. Therefore, 0.6 mL potassium phosphate containing 2.4 mEq of potassium and 5.3 mEq of phosphate was administered through a nasogastric tube. The patient showed rapid response after a single dose through the nasogastric tube. Such an intervention in Sanjad-Sakati syndrome patients shows possible advantages of shifting drug administration from intravenous to oral route that includes a convenient route of administration, whether in the intensive care unit or in the general ward. Moreover, shifting drug administration from the intravenous to oral route overcomes the risk of cannula-induced infection and reduces nurses' workload.

Item Type:	Article
Uncontrolled Keywords:	32 Biomedical and Clinical Sciences; 3202 Clinical Sciences; Infectious Diseases; Pediatric; Rare Diseases; Emerging Infectious Diseases; 6.1 Pharmaceuticals; 32 Biomedical and clinical sciences; 42 Health sciences
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	SAGE Publications
Date of acceptance:	28 December 2020
Date of first compliant Open Access:	14 July 2025
Date Deposited:	14 Jul 2025 10:11
Last Modified:	14 Jul 2025 10:15
DOI or ID number:	10.1177/2050313x20988412
URI:	https://researchonline.ljmu.ac.uk/id/eprint/26773

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