Basal metabolic requirements, biomarkers of cardiometabolic health and anthropometric measures of obesity in adults with restricted growth conditions

Atkinson, G ORCID: 0000-0002-5459-9042 Basal metabolic requirements, biomarkers of cardiometabolic health and anthropometric measures of obesity in adults with restricted growth conditions. American Journal of Medical Genetics, Part A. ISSN 1552-4825 (Accepted)

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Abstract

Population-specific thresholds have not been defined for the levels of adiposity and systemic biomarkers that predict chronic health risks in people with restricted growth conditions. Here, anthropometric measures of adiposity, basal metabolic requirements and fasted blood samples were obtained from adults with restricted growth (age 41±14 years, height 1.30±0.10 m, body mass 60.5±18.3 kg, female:male n=24:13, achondroplasia n=26; mean±SD). Basal metabolic rate was 6529 ± 1703 kJ∙d-1 and total mass-normalised energy requirements were higher for females versus males. Plasma concentrations of glucose (5.55±0.73 mmol • L-1), insulin (36.4±19.9 pmol • L-1) and lipids (triacylglycerol 0.84±0.37 mmol • L-1; total cholesterol 4.54±0.85 mmol • L-1; high-density lipoprotein cholesterol 1.41±0.31 mmol • L-1; low-density lipoprotein cholesterol 2.73±0.69 mmol • L-1) were mostly within healthy clinical reference ranges. Sagittal abdominal diameter was positively correlated with plasma glucose and leptin concentrations (r=0.85; 95%CI: 0.61, 0.95; p<0.0001, and r=0.85; 95%CI: 0.61, 0.95; p<0.0001, respectively). Mean±SD body mass index (BMI) was 36.1±11.0 kg·m-2. However, we found that body mass scaled to height by the power of 1.4 (95%CI: 0.2, 2.6) rather than 2 associated with conventional BMI. Conventional biomarkers of cardiometabolic health are not substantially elevated in these individuals with restricted growth despite the classification of obesity using height-dependent references (e.g., traditional BMI).

Item Type:	Article
Uncontrolled Keywords:	0604 Genetics; 1103 Clinical Sciences; 3105 Genetics; 3202 Clinical sciences
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport and Exercise Sciences
Publisher:	Wiley
Date of acceptance:	31 July 2025
Date Deposited:	31 Jul 2025 09:18
Last Modified:	31 Jul 2025 09:30
URI:	https://researchonline.ljmu.ac.uk/id/eprint/26870

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