Stroke-Heart Syndrome and risk of incident dementia among patients with first-ever ischaemic stroke: A territory-wide population-based cohort study

Buckley, B ORCID: 0000-0002-1479-8872 (2025) Stroke-Heart Syndrome and risk of incident dementia among patients with first-ever ischaemic stroke: A territory-wide population-based cohort study. Alzheimer's & Dementia, 21 (9). ISSN 1552-5260

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Abstract

INTRODUCTION The risk of dementia in patients with ischemic stroke and early cardiovascular complications (i.e., stroke–heart syndrome [SHS]) remains underexplored. METHODS Patients with first-ever ischemic stroke in Hong Kong between 2005 and 2020 were included. Multivariable Fine–Gray competing risk analysis was performed after 1:1 propensity score matching to evaluate the association between SHS and the risk of dementia. RESULTS Of the 130,605 included patients with ischemic stroke, 12,696 (9.7%) patients developed SHS. Patients with SHS had a 19% increased risk of dementia compared to those without SHS at 1 year post-stroke, driven mainly by vascular dementia. This increased risk gradually declined and became non-significant after 3 years post-stroke. Appropriate antithrombotic therapy and comorbidities optimization were associated with a 32% reduced dementia risk in patients with SHS. DISCUSSION SHS is associated with an increased risk of incident dementia. Appropriate antithrombotic therapy and comorbidities optimization post-stroke may reduce this heightened risk of cognitive impairment.

Item Type:	Article
Uncontrolled Keywords:	Humans; Dementia; Incidence; Risk Factors; Cohort Studies; Comorbidity; Aged; Middle Aged; Hong Kong; Female; Male; Propensity Score; Ischemic Stroke; ABC pathway; cardiovascular complications; cognitive impairment; dementia; integrated care; ischemic stroke; stroke; stroke–heart syndrome; Humans; Male; Female; Ischemic Stroke; Dementia; Aged; Hong Kong; Cohort Studies; Incidence; Risk Factors; Middle Aged; Propensity Score; Comorbidity; 1103 Clinical Sciences; 1109 Neurosciences; Geriatrics; 3202 Clinical sciences; 3209 Neurosciences; 5202 Biological psychology
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport and Exercise Sciences
Publisher:	Wiley
Date of acceptance:	24 August 2025
Date of first compliant Open Access:	22 September 2025
Date Deposited:	22 Sep 2025 13:03
Last Modified:	22 Sep 2025 13:15
DOI or ID number:	10.1002/alz.70716
URI:	https://researchonline.ljmu.ac.uk/id/eprint/27190

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