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Bailey, TG, Cable, T, Aziz, N, Atkinson, G, Cuthbertson, DJ, Low, DA and Jones, H (2015) Exercise training reduces the acute physiological severity of post-menopausal hot flushes. Journal of Physiology. ISSN 1469-7793
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Abstract
A hot-flush is characterised by feelings of intense heat, profuse elevations in cutaneous vasodilation and sweating, and reduced brain blood flow. Exercise training reduces self-reported hot-flush severity, but underpinning physiological data are lacking. We hypothesised that exercise training attenuates the changes in cutaneous vasodilation, sweat rate and cerebral blood flow during a hot flush. In a preference trial, 18 symptomatic post-menopausal women underwent a passive heat stress to induce hot-flushes at baseline and follow-up. Fourteen participants opted for a 16-week moderate intensity supervised exercise intervention, while 7 participants opted for control. Sweat rate, cutaneous vasodilation, blood pressure, heart rate and middle cerebral artery velocity (MCAv) were measured during the hot-flushes. Data were binned into eight equal segments, each representing 12.5% of hot flush duration. Weekly self-reported frequency and severity of hot flushes were also recorded at baseline and follow-up. Following training, mean hot-flush sweat rate decreased by 0.04 mg·cm2 ·min-1 at the chest (95% CI: 0.02-0.06, P = 0.01) and by 0.03 mg·cm2 ·min-1 (0.02-0.05, P = 0.03) at the forearm, compared with negligible changes in control. Training also mediated reductions in cutaneous vasodilation by 9% (6-12) at the chest and by 7% (4-9) at forearm (P≤0.05). Training attenuated hot flush MCAv by 3.4 cm/s (0.7-5.1, P = 0.04) compared with negligible changes in control. Exercise training reduced the self-reported severity of hot-flush by 109 arbitrary units (80-121, P<0.001). These data indicate that exercise training leads to parallel reductions in hot-flush severity and within-flush changes in cutaneous vasodilation, sweating and cerebral blood flow
| Item Type: | Article |
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| Additional Information: | This is the peer reviewed version of the following article: Bailey, T. G., Cable, N. T., Aziz, N., Atkinson, G., Cuthbertson, D. J., Low, D. A. and Jones, H. (2015), Exercise training reduces the acute physiological severity of post-menopausal hot flushes. J Physiol. which has been published in final form at http://dx.doi.org/10.1113/JP271456 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Wiley |
| Date Deposited: | 21 Jan 2016 10:03 |
| Last Modified: | 23 Jan 2024 14:00 |
| DOI or ID number: | 10.1113/JP271456 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/2726 |
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