Enhancing healthspan with Ashwagandha (Withania somnifera): a comprehensive review of its multifaceted geroprotective benefits

Vittal, M ORCID: 0000-0003-2617-8133 and Vinciguerra, M ORCID: 0000-0002-1768-3894 (2025) Enhancing healthspan with Ashwagandha (Withania somnifera): a comprehensive review of its multifaceted geroprotective benefits. Biogerontology, 26 (5). p. 179. ISSN 1389-5729

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Abstract

Ashwagandha (Withania somnifera), a revered herb in Ayurvedic medicine, has gained significant scientific recognition for its potential to promote healthy aging. Traditionally used as a Rasayana or rejuvenator, this potent adaptogen helps the body manage stress and enhance vitality. This review synthesises extensive evidence for its multifaceted anti-aging capabilities, which target key hallmarks of the aging process. The mechanisms underpinning its effects include enhancing telomerase activity to support cellular longevity, combating systemic oxidative stress, and powerfully countering inflammaging by modulating immune responses and lowering inflammatory markers like C-reactive protein. Robust clinical evidence demonstrates its efficacy in improving crucial physiological parameters, including significant gains in muscle strength and size, enhanced cardiorespiratory fitness, hormonal balance, skin health, and improved sleep quality in older adults. Furthermore, trials have consistently shown its ability to improve cognitive function, including memory and information-processing speed, particularly in adults with mild cognitive impairment. Promising preclinical data also highlight its neuroprotective potential in models of Alzheimer’s and Parkinson’s disease. Here, we review the current evidence supports Ashwagandha’s therapeutic potential in extending healthspan and enhancing quality of life. Large-scale, long-term clinical trials using standardized extracts are essential to fully confirm its role in healthy aging within the global population.

Item Type:	Article
Uncontrolled Keywords:	Animals; Humans; Withania; Plant Extracts; Medicine, Ayurvedic; Oxidative Stress; Aging; Longevity; Quality of Life; Healthy Aging; Adaptogen; Aging; Ashwagandha; Healthspan; Inflammaging; Neuroprotection; Humans; Withania; Plant Extracts; Healthy Aging; Longevity; Animals; Quality of Life; Medicine, Ayurvedic; Oxidative Stress; Aging; 3206 Medical Biotechnology; 32 Biomedical and Clinical Sciences; Behavioral and Social Science; Dementia; Aging; Clinical Trials and Supportive Activities; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Clinical Research; Acquired Cognitive Impairment; Neurosciences; Neurodegenerative; Brain Disorders; 1.1 Normal biological development and functioning; 5.1 Pharmaceuticals; Neurological; Inflammatory and immune system; Humans; Withania; Plant Extracts; Healthy Aging; Longevity; Animals; Quality of Life; Medicine, Ayurvedic; Oxidative Stress; Aging; 1103 Clinical Sciences; Gerontology; 3202 Clinical sciences
Subjects:	R Medicine > RA Public aspects of medicine R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Springer
Date of acceptance:	29 August 2025
Date of first compliant Open Access:	3 October 2025
Date Deposited:	03 Oct 2025 12:37
Last Modified:	03 Oct 2025 12:45
DOI or ID number:	10.1007/s10522-025-10320-0
URI:	https://researchonline.ljmu.ac.uk/id/eprint/27263

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