Associations of plasma p-tau231 with serial position recall performance in free-of-dementia individuals

Bruno, D ORCID: 0000-0003-1943-9905, Reichert-Plaska, C, Jauregi-Zinkunegi, A, Ashton, NJ, Zetterberg, H, Blennow, K and Pomara, N (2025) Associations of plasma p-tau231 with serial position recall performance in free-of-dementia individuals. Journal of Neuropsychology. ISSN 1748-6645

Preview

Text Associations of plasma ptau231 with serial position recall performance in free of dementia individuals.pdf - Published Version Available under License Creative Commons Attribution. Download (343kB) | Preview

Abstract

Cognitive assessment and analysis of plasma biomarkers are lower-cost options for the early assessment of Alzheimer's disease (AD). In this study, we examined whether serial position markers in the Rey's AVLT were sensitive to plasma AD biomarkers in cognitively unimpaired older individuals. Participants (n = 327; mean age = 70.4, SD = 10.4) were free of dementia (MMSE = 24+) at baseline and recruited as part of the Memory Evaluation Research Initiative (MERI; Nathan Kline Institute, NY, USA). Data included plasma p-tau231, Aβ40 and Aβ42, AVLT scores and demographics. Bayesian linear and logistic regression analyses were carried out with plasma biomarkers as outcomes (including the Aβ42/40 ratio); memory scores, including traditional metrics and serial position scores, were predictors; and age, years of education, APOE ε4-status and reported gender were control variables. Results indicated that plasma p-tau231 was associated primarily with delayed primacy recall (first four words): the more primacy words were recalled, the lower the plasma p-tau231 levels were. This study confirms that serial position analysis of word-list recall data, and particularly delayed primacy, is a valuable tool for the identification of in vivo AD-related pathology in cognitively unimpaired individuals.

Item Type:	Article
Uncontrolled Keywords:	Alzheimer's disease; memory assessment; plasma biomarkers; 5202 Biological Psychology; 52 Psychology; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Brain Disorders; Dementia; Prevention; Alzheimer's Disease; Acquired Cognitive Impairment; Aging; Clinical Research; Neurodegenerative; Neurosciences; Neurological; 11 Medical and Health Sciences; 17 Psychology and Cognitive Sciences; Experimental Psychology; 3202 Clinical sciences; 3209 Neurosciences; 5202 Biological psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Divisions:	Psychology (from Sep 2019)
Publisher:	Wiley on behalf of The British Psychological Society
Date of acceptance:	10 September 2025
Date of first compliant Open Access:	6 October 2025
Date Deposited:	06 Oct 2025 11:59
Last Modified:	06 Oct 2025 12:15
DOI or ID number:	10.1111/jnp.70012
URI:	https://researchonline.ljmu.ac.uk/id/eprint/27276

View Item